Excerpts

Furthermore, there was a highly significant positive correlation (r = 0.932, p = 3.7 × 10 -11 ) for the relative expression of the 8 genes relative to control (Figure 3 ) between qPCR and SuperSAGE, indicating an overall concordance between the two techniques in detecting differential expression.

A highly significant difference was observed for CAI ( p < 3.7 × 10 −11 ), indicating substantial host-associated variation in codon adaptation.

In paired comparisons of the different materials with the identical surface treatments, all groups showed highly significant differences (groups 1 and 4 p = 3.728 × 10 –11 ; groups 2 and 5 p = 7.721 × 10 –6 ; groups 3 and 6 p = 1.725 × 10 –6 Figure 6 ). 3.2.2.

A chi-square test showed a highly significant difference in the distribution of cases across age groups (p = 3.78 × 10 − 11), with a disproportionately higher number of cases among young adults aged 25–39 years.

In particular, differences in allele frequencies were highly significant between the B and D groups and between the M and D groups ( P = 3.78E − 11 and P = 3.95E − 9, respectively.

After adjusting for LYZ expression, the trans association observed with rs317657 were reduced, but remained highly significant, p = 3.88×10 −11 , p = 1.15×10 −7 , p = 2.52×10 −6 , p = 1.65×10 −10 , p = 7.16×10 −29 , p = 2.44×10 −5 , p = 8.23×10 −28 , p = 1.81×10 −13 , p = 5.66×10 −10 for CNTN6 , CTRC , COPZ2 , KRT9 , LRRFIP1 , NOD1 , PCDHA6 , ST5 and TRAF3IP2 , respectively.

For example, Lu and Cantor describe a method that allows for sex-specific associations, resulting in highly significant findings at the ryanodine receptor 2 locus ( P <3.9 × 10 -11 ) in a multiplex autism dataset [ 8 ].

Among variants tested for association in GTEx, we observed a highly significant eQTL for TMPRSS2 expression at rs35074065 (p=3.9 × 10 −11 ) as well as more nominal eQTL evidence at rs1557372 (p=2.9 × 10 −5 ) and rs9974995 (p=3.5 × 10 −6 ).

72 Several studies demonstrated a strong association between DISH and MS: Mader et al confirmed this based on WHO criteria, 73 Vezyroglou et al reported metabolic abnormalities in 70% of DISH patients versus 45% of controls (p<0.0001) 74 and the AGES-Reykjavik Study found a highly significant association (OR 2.12, 95% CI 1.69 to 2.64, p=3.9×10−11), mainly driven by BMI and blood glucose criteria. 75 Association with excess body weight and body fat composition DISH is strongly linked to excess body weight, particularly central obesity measured by waist circumference. 6 9 54 56 60

The two-way ANOVA (response: OD at 517 nm; factors: Treatment and Experiment) indicates a highly significant main effect of Treatment (F 2 ,12 = 319.43, p = 3.93 × 10−11), demonstrating that absorbance differs markedly among the control, thyme oil, and cinnamon oil groups.

The model was highly significant ( p ‐value = 3.952e −11 ; adjusted R 2 = 0.929).

This locus achieved highly significant linkage under all three non-parametric models (max NPL=6.73, P =4.0 × 10 −11 ).

These plots demonstrate significant differences in CCL5 expression across these immune subtypes, with p-values from Kruskal–Wallis tests reaching highly significant levels (p < 4.19e-11 for KIRC and p < 1.04e-08 for ESCA).

In the meta-analysis, one SNP, rs3987 at 4q26, reached GWAS significant p-value (p = 4.02×10 −8 ), and one SNP pair, rs1100508 CG and rs8111948 AA, showed a trend for two-locus association (p = 4.35×10 −11 ).

Using STRINGv11.0 program with the highest confidence interaction score (CIS) of 0.9, processing the 119 genes yielded a protein–protein interaction network of 70 genes, which was found to be highly significant based on hypergeometric test with Benjamini–Hochberg correction ( p = 4.36 × 10 −11 ) ( Figure 2 a).

The results of the two-way ANOVA test showed a highly significant effect of polymer type on in vitro erosion time ( p -value = 4.38 × 10 −11 , less than 0.001), whereas the tube diameter had no significant effect ( p -value = 0.175 > 0.05).

However, we see a highly significant overlap between DEGs in our current study and DEGs reported when ELS and AS was experienced in the same animal (Fig. 6A ) (OR = 2.5, P = 4.5 × 10 −11 ).

Interestingly, for cluster 2 (genes with increased expression during heat stress in TM broilers), Forkhead box protein M1 (FOXM-1) was a candidate upstream regulator displaying a highly significant P -value of overlap ( P = 4.51e -11 ).

The likelihood ratio test between the maximum likelihood three-epoch and two-epoch models was highly significant ( p = 4.52×10 −11 ), showing that at least three periods of different population sizes must be considered to describe the data.

The Kruskal-Wallis H test revealed a highly significant difference (p = 4.611e-11) ( S2 Fig ).

In contrast, the decline of LZCkm was modest, showing a decrease by no more than ∼20%, albeit the change was also highly significant statistically ( P = 4.6442e-011).

Analysis of the ITGAM coding variant rs1143679 showed highly significant association to DLE in patients without signs of systemic disease ( P -value = 4.73×10 −11 , OR = 3.20, 95% CI = 2.23–4.57).

Using the Fisher's exact test, the overlap between DREAM-binding genes and CHR-containing genes appears to be highly significant ( P = 4.8 × 10 −11 ).

Finally, we observed a highly significant association of age with weighted transitivity ( F 1651 = 44.74, p ‐value = 4.86 × 10 −11 ), which persisted also when including the additional variables (degree, GMV, HC‐use, MC‐phase).

When comparing the frequency of observed de novo variation to the expected background frequency of de novo missense or loss-of-function variation in RALA (6.16 x 10 −6 per chromosome) [ 17 ], we find a highly significant enrichment for de novo variants in affected probands (8 observed de novo variants in 32172 screened alleles vs. 0.198 expected, Exact Binomial test p = 4.93 x 10 −11 ).