Excerpts

Other important and highly significant categories were response to stress (1514 genes, padj-value = 5.69E-24) and developmental process (1280 genes, corrected p -value = 8.09E-12).

Four probands had rare damaging mutations (2 de novo) in TFAP2B , a transcription factor that orchestrates neural crest cell migration and differentiation; this mutation burden is highly significant ( P = 8.2 × 10 −12 ).

We repeated this test using human RH and mouse aneuploidy data (1,213 orthologous genes) and found a highly significant overlap of 131 genes with negative cis α ( P = 8.2 × 10 -12 ).

A decreasing trend of PRDM1 transcript expression in PBMC was also observed from Q1 to Q4 of FOXO1 transcript expression (ANOVA p = 8.25 × 10 −12 , Fig. 1 c).

STRING protein interaction analysis yielded a highly significant protein-protein interaction (PPI) score (PPI score p = 8.26e- 12 ), suggesting these proteins might directly interact or work together in common pathways (Fig. 1 D).

Group differences in PANSS-EC total score were highly significant with OR 1.2, FDR-adjusted p = 8.3 × 10 −12 .

Bmp6 mutants showed a highly significant ( P = 8.5 x 10 −12 ) decrease in the expression of stickleback orthologs of these genes ( Fig 6E and 6F ).

The correlation between our CNV prediction and PCR validation was highly significant (P = 8.92E-12) (Additional file: Figure S2 ).

Although highly significant (one-sided Pearson P = 9 × 10 −12 for RSA and P = 2 × 10 −4 for DTL), the magnitude that ns-polymorphism distributions shift with respect to DTL and RSA was subtle: Across samples, the mean DTL of ns-polymorphism varied by less than 1 Å, and the mean RSA varied between 0.34 and 0.38.

Interaction of the proteins from the protein-coding genes seen in Figure S2 revealed a highly significant network ( p = 9.04 × 10 −12 ) with 76 connections, an average node degree of 2.53, an average local clustering coefficient of 0.382, and a maximum interaction score of 0.50.

The Jonckheere–Terpstra test (two-sided) showed a significant trend for growth and aging, with JT = 22 and P = 9.151 × 10 −12 .

Phonophobia was reported by 90.32% of dVM patients during the IC phase, but only 6.45% in the II phase, indicating a highly significant difference ( p = 9.336 × 10 −12 ).

The interaction was highly significant ( P = 9.52 × 10 −12 ), confirming that difference in gene expression between the vertically inherited homolog and donor ortholog is significantly greater in putatively stable laterally acquired genes than in degenerating ones.

The difference in the FCI between the two species is highly significant (two-sided t test P = 9.796e-12).

However, we obtained a highly significant HWE deviation (P=9.8×10 -12 ) in the control group.

Results Pooled results indicated a highly significant association between COMT Val158Met and antipsychotic response (Z = 6.709, P = 9.8 × 10 -12 ).

The overlap in these 83 genes was highly significant by the hypergeometric test ( P < 9.87e-12).

The preponderance of significant negative correlations with ORF length among eukaryotes is itself highly significant, for both 5′-mRNA folding energy (binomial P < 10 −11 ) and 5′-CAI (binomial P < 10 −9 )—suggesting a systematic eukaryotic trend toward faster translation initiation and faster early elongation in short versus long genes.

Expanding the observation to cells that showed morphological changes, including elongation, that preceded divisions, another 87 cells appeared to be preparing for division in aggregates while none of the isolated cells showed any shape change, which was a highly significant difference (24.3% vs 0%, two-sided p< 10 - 11).

A generalized linear regression model with output SRT benefit modeled just from avREOIG (i.e., SRT benefit ∼ 1+ avREOIG) showed both intercept ( p < 10 −22 ) and avREOIG ( p < 10 −11 ) to be highly significant factors with an overall r 2 = 0.371 ( p < 10 −11 ), that is, 37.1% explained variance.

Highly significant differences were observed in the level of clustering, or transitivity ( F = 86, p = 10 −11 ), however, with the antigens showing strong clusters separated from each other.

When we examine spontaneous avoiding reactions of freely swimming paramecia, we find that both backward swimming duration and reorientation angle vary broadly (156 ± 81 ms and 114 ± 66°, respectively) ( Fig 9H ), and there is a small although highly significant correlation (linear regression, r = 0.2, p = 10 −11 ).

In Mp toc1 ko mutants, expression of Mp PRR was continuously high and arrhythmic, as indicated by highly significant effects of both genotype (G) and genotype x time interaction (GxT) terms in ANOVA ( P < 10 −11 ), suggesting that MpTOC1 represses Mp PRR .

8 b) and had highly significant enrichment of interactions between them (STRING: expected number of edges: 5; number of edges: 28; PPI enrichment p-value: ****p < 1 × 10 –11 ) , while random samples of 43 peaks from either all GWAS ALS genes or from all epiChromALS peaks showed no functional enrichment, suggesting a mechanistic link between these genes, neuronal development/function, and epigenetic mechanisms.

In contrast, the difference between double conditions was large and highly significant (D + : median 1.27, D − : median: 0.63, z = 7.1481, Bonferroni corrected p < 10 −11 , Wilcoxon signed-rank test).