Excerpts

The final model generated by SRL included gene-environment interaction terms for ten lifestyle factors ( S10 Table , supplementary Data), of which eight were nominally significant: alcohol intake frequency ( p = 2.82*10 −15 ), usual walking pace ( p = 1.55*10 −14 ), frequency of 10+ minute walks ( p = 6.26*10 −4 ), smoking status (p = 1.45*10 −3 ), frequency of vigorous exercise ( p = 2.28*10 −3 ), number of vehicles in household (p = 1.03*10 −2 ), TDI (p = 3.02*10 −2 ) and frequency of tiredness/lethargy (p = 3.87*10 −2 ) and.

7f ), other T cell subtypes, such as Tregs showed a decreasing trend (adjusted one-sided JT p value = 2.96 × 10 −15 ) (Fig. 7g ), suggesting diverse etiology of clusters linked to size.

18 (−6.32 × 10 −16 ; bp 10993468) There were three other highly significant SNPs ( p < 3 × 10 −15 ) in chr. 4 (bp 85884362 to 85884367; solutions 2.167).

Our gene prioritization approach identified seven of 16 mtDNA depletion genes (Supplemental Table 13), consistent with a highly significant enrichment (one-sided p = 3.09 × 10 –15 ).

2014 ) confirmed a highly significant and consistent down-regulation of these genes in PRANCR -depleted keratinocytes ( P -value = 3.2 × 10 −15 ) ( Fig. 5 E).

Comparing all the data with respect to the 0 baseline, 169 mRNA were higher in BA but more than double that were higher in CH (345), a highly significant deviation from the null expectation of 50:50 equilibrium ( P =3.21 e −15 ; binomial test statistic).

However, our reanalysis revealed a highly significant difference (p = 3.3e −15 ) using the same statistical test as in 1 due to the numerous, large LPF on mysticete palates (Fig. 3 b–f, Fig.

A highly significant difference was observed between the two study areas ( p = 3.4 × 10 −15 ), and between the dry and wet seasons ( p = 0.005).

a sample-wide average of 0.262 (± 0.140) a highly significant difference (Mann-Whitney U Test, p -value = 3.5 × 10 −15 ).

Considering our head (252 genes) and body (1,940 genes) datasets separately, and assuming 14,000 total genes in the Drosophila genome, the number of genes that intersect between our study and three or more other sets of age-related genes is highly significant (all p -values < 3.7 × 10 −15 ).

The detected PKD2 variant is absent from the GnomAD and ClinVar databases, but we found its association with CKD highly significant (OR > 1000, p = 3.7 × 10 −15 ).

Detailed analyses of the gene expression network using publically-available ChIP-seq data ( http://genome.ucsc.edu/ENCODE/analyses ) revealed that there was a highly significant overrepresentation ( p = 3.8E−15) of MYC binding at the promoter regions among the positively correlated genes (29 of the 35 positively correlated genes), in relation to the negatively correlated genes (6 of the 67 genes) (Supporting Information Tables S3 and S4 ).

Early-onset PE had two highly significant gene modules: the yellow module (r = 0.73, p = 4e-15) with 112 DEGs enriched in biological processes related to gonadotrophin secretion and lipid storage, and the black module (r = −0.55, p = 5e-08) with 47 DEGs significantly enriched in chronic inflammation responses.

Replicates had highly significant Spearman rank correlation coefficients of 0.74–0.94 ( p = 4 × 10 −15 to 3 × 10 −24 ) per pair.

We found a highly significant proportion of RasD-dependent genes (36 out of 45; hypergeometric test; p = 4 × 10 −15 ) were also affected by nutritional history (>1.5 × increase or decrease in expression).

Indeed, we identified a highly significant QTL (-log 10 ( P -value) = 14.36) on chr10 across the 3 phenotypic datasets for Tuber Shape, which was detected both with SNP and haplotag markers ( Fig. 7 , Supplementary File 9 ).

Despite the spread attributable to differences in etiology, the association between EES groups appears highly significant, with Fisher’s exact test p—value = 4.4 × 10 −15 .

Comparing the number of diagnostic transitions observed 5′ and 3′ of the respective preferred crosslinking site, we found highly significant differences in CSD and ZKD crosslinking patterns (ZKD p = 4.7e-15; CSD p = 4.9e-06) ( Fig. 4D ).

This was shown by way of a simple one sample t-test, which for control plants indicated the distribution of response ratio across samples was not significantly different to 1 (theoretical mean for a distribution based on plants with no CO 2 response) at p < 0.05, whereas deviation from this limit among test plants was highly significant (p = 4.72e -15 ) ( S4 Fig ).

Further inspection of GO revealed that this was due to the highly significant overrepresentation of genes for mitochondrial proteins (GO:0005739, P = 5 × 10 -15 ).

Because the correlation between the two ROIs was positive in every subject, the group-level statistic was highly significant (sign test, p < 5 x 10 −15 ).

There was a highly significant association between childhood emotional abuse and NR3C1 methylation ( b =1.06; P =5.11 × 10 −15 ) showing that emotionally abused subjects had higher methylation status (0.135 (s.d.=0.03)) than non-emotionally abused subjects (0.098 (s.d.=0.03); Supplementary Figure S1 ).

Double-labelling with antibodies to Smo and to acetylated tubulin (which marks stable microtubules found in cilia) revealed a highly significant accumulation of Smo in the cilia of NIH-3T3 cells upon addition of ShhN ( Fig. 6 B,G; χ 2 =61.19, d.f.=1, n =157 cells, P =5.16×10 −15 ) whereas, in the absence of ShhN, cilia are largely devoid of Smo ( Fig. 6 A,G) ( Rohatgi et al., 2007 ).

3 C and F ), and in the full dataset, it remains highly significant even if interface size is included as a covariate with P = 5.9e −15 for the full dataset and P = 0.27 for the human dataset in an analysis of covariance (ANCOVA).

Notably, highly significant GO terms included skeletal system development (p = 6.1e-15), collagen fibril organization (p = 1.5e-15), extracellular matrix organization (p = 5.8e-13), and roof of mouth development (p = 4.7e-13).