Excerpts

The overall regression was found to be highly significant (R 2 = 0.641, F(7680) = 173.2, p < 6.4 × 10 −15 ).

We found that the sep-1(ts) mutant grown at permissive temperature showed a highly significant reduction in the number of apoptotic corpses (average of 2.4 ± 1.2 corpses; n = 53; p = 6.4 × 10 −15 ) at the “comma” stage of embryogenesis compared to that in wild type (N2) embryos (average of 4.4 ± 1.2; n = 121; Fig. 1B ).

This optimal model predicted PPB fraction in diet negatively affecting FCR ( p = 4 × 10 −7 , fraction of variance 0.12) with a highly significant interaction between time*diet type ( p = 7 × 10 −15 , fraction of variance 0.6).

Welch’s test confirmed a highly significant difference in mean pressure between groups, with higher values observed during intramuscular infusion, mean difference = 0.1430, t = 11.5990, p = 7.22 × 10 −15 , 95% CI: [0.1181, 0.1679].

First, as previously reported for various eukaryotes [ 63 , 64 ] most introns were inserted in phase 0 (40.2% of all introns) or phase 1 (38%), with a highly significant underrepresentation of intron insertions in phase 2 (21.8%; c 2 = 64.68, P = 8.98e -15 ; Figure 2a ).

Inversely, a statistically highly significant DEHP-induced decreased reads numbers (p = 9*10 −15 ) was observed in Tmem125 promoter region in MBDseq experiment in C57BL/6J controls (19.8±3.9) compared with DEHP300 (0.9±3.9%), ( Fig 5B ), consistent with a DEHP-induced decreased methylation levels recorded in pyrosequencing experiment in CpG 1 although not statistically significant (p = 0.7) in C57BL/6J controls (69±4%) compared to DEHP300 (65±10%), ( Fig 5C ).

However, for the Japanese cohorts, the difference between females and males was highly significant in the discovery stage ( P = 9.47E−15) and replication stage ( P = 2.71E−14) (Supplementary Table 2).

In contrast, the P3 tau peptide (residues 25-44) was less correlated to immunoassay measurements (cor = 0.78), yet still highly significant (p = 9.73e−15).

This correlation was highly significant for each of the 30 pairwise comparisons ( P < 1.0 × 10 −14 ).

Positive correlations between the differentially expressed genes The Pearson Correlation test performed between the 115 significantly changed transcripts in all 59 patient and control samples identified 54 highly significant correlations (threshold: r > 0.8 and P < 10 -14 , Additional file 5 , Table S4).

This analysis confirmed that human observers exhibited much lower SSNR thresholds than DNNs, outperforming the DNNs by a highly significant margin at recognizing objects in pixelated noise ( t (26) = 15.94, p < 10 −14 ); they also outperformed DNNs at recognizing objects in Fourier phase-scrambled noise ( t (26) = 12.29, p < 10 −11 ).

The overlap (25%, 57 genes) between the S2 cell screen (227 genes identified; Table S6 ) and our genome-wide study on Kc 167 cells (526 genes identified) was highly significant ( p < 1e −14 , Wilcox test).

These contrasting trajectories were supported by statistical analyses: in cluster 1, differences between batches emerged as early as 2 hpi and remained highly significant thereafter ( P <1×10 −14 at 24 hpi); in cluster 2, divergence became significant from 8 hpi onward, with very big differences at 18 hpi and 24 hpi ( P <1×10 −10 and P <1×10 −65 , respectively); and in cluster 3, batches remained comparable until a pronounced difference appeared at 24 hpi ( P <1×10 −10 ) ( Fig. 4 ).

For the two metrics, the difference in performance is highly significant between each pair of models (p < 10 −14 ).

all β m being equal), which led to a highly significant deterioration of the likelihood function ( P value <10 −14 ).

Of the 871 SNPs with a C2 value above 60 (corresponding to a highly significant association, P < 10 −14 ), 867 were located in the middle of the X chromosome.

A correlation analysis of the Spearman rho statistics between the two clusters is highly significant (rho = 0.39, p < 10 -14 ; using newborns declared as only one race, N = 162, rho = 0.41, p < 10 -14 ), indicating that similar trends exist in both groups.

Focusing on the 1 Mb region surrounding each gene (and correcting for cancer type and CNA), 82 genes with FDR < 10% for each dataset overlapped between both results sets, a highly significant overlap ( p < 1E−14, one-sided Fisher’s exact test, Fig. 2 d).

In the presence of BI-D, HIV-Luc integrated into genes about 66% to 70% of the time in WT and HKO cells, which were highly significant differences from baseline ( p < 10 −14 ).

HMGCR, although not listed as top five key drivers, was a highly significant key driver ( P < 10 −14 ).

This enrichment was highly significant ( P < 10 −14 , Fisher's exact test), suggesting that super-enhancers may indeed drive the high expression of numerous key EMT genes.

By Fisher's exact test, this enrichment is highly significant ( p -value = 1 × 10 −14 ) in comparison to the global data in which oxidation represents <5% of observed modifications ( Fig. 2 D ).

The results demonstrate a highly significant association between resistance and each of the five SNP markers tested from 10.01 to 10.63 Mb on chromosome 27 ( P < 10 –14 for each marker, SI Appendix , Table S4 ).

PERMDISP analyses revealed significant within‐group variability at both class and ASV levels (bacteria: F = 8.98, p < 0.001; fungi: F = 7.59, p = 0.014; bacterial ASVs: F = 67.93, p = 0.000; fungal ASVs: F = 10.12, p < 0.001), while posthoc PERMANOVA confirmed highly significant temporal shifts, particularly in fungal classes and ASVs ( p < 1 × 10 −14 ) (Tables S2 and S3 ).

2 B, the time required to curate each case demonstrates a leftward shift in the distribution for S-BCAW relative to MICAW, with a highly significant difference ( p = 1.07E-14).