Excerpts

This revealed a highly significant association between the risk scores and the survival of the patients (Figure 2C ; log rank test P < 10 −15 ).

At 2 hpi, highly significant ρ values of 0.68 ( P < 1.0 × 10 −15 ) and 0.67 ( P < 1.0 × 10 −15 ) were observed for the MAP-infected and control sample groups, respectively.

We also found that the interaction term was highly significant ( P < 10 −15 ), indicating that the effect of the HULK genes on flowering time was non-additive (i.e. epistasis was apparent).

Quantification of glial nuclear basket ::GFP levels normalized to the oil vehicle control (1.0 ± 0.029, n = 13; 10 nuclei averaged per data point) shows a highly significant ~ 200% mean nuclear elevation following critical period EB experience (1.904 ± 0.030, n = 17; t (28) = 21.24, p < 1.0 × 10 −15 , two-tailed unpaired t- test; Fig. 5 B).

A massive and highly significant ( p -value <10 −15 ) decrease of TAT expression is observed in tumors as compared to their adjacent tissue in most of the samples (87/112, median decreased of 20 fold, Fig. 6 ).

There was a highly significant interaction for both DCV and FHV (Cox's mixed-effect models; DCV: χ 2 = 127.4, d.f. = 19, P <10 −15 ; FHV: χ 2 = 107.6, d.f. = 19, P <10 −14 ).

In contrast, a robust and highly significant increase was found in the dopaminergic neurons of α-Syn zebrafish under identical conditions (α-Syn post-MPP + 1.73 ± 0.09; p < 10 −15 vs . baseline, 2-way ANOVA with Tukey multiple comparisons test; Fig. 5 E).

As further validation, we constructed a linear model with expression divergence as the dependent variable, and the 11 tested factors and d N as explanatory variables; d N remained highly significant in this analysis ( P < 10 − 15 ).

The overlap of DTA and DGE events identified across all three data sets was highly significant (phyper P < 1 × 10 −15 ), confirming the robustness of our findings.

One-sided Wilcoxon matched-pairs signed-rank tests (paired by subject and parcel) confirmed that these differences were highly significant ( p < 10 −15 ) across all comparisons, with SA consistently outperforming P3 and P3MT.

All three pairwise within-individual differences between wake, NREM, and REM slopes were highly significant ( p < 10 −15 matched-pair t tests) and similar results were obtained for C3-M2 (Extended Data Figs. 1-2 , 1-3 ).

Likewise, it is intriguing that there is a highly significant overlap (p < 10E −16 , Fisher’s exact test) between the transcripts identified as PTZ stimulated, particularly those that are downregulated, and those described previously as bound to astrocyte ribosomes in perisynaptic fractions ( Sakers et al., 2017 ).

The baseline method ROTS that ignores longitudinal trends also performed well with an IQR mean pAUC of 0.941, while the difference to the best performing method RolDE was highly significant ( p < 10 −15 ).

These values are consistent with previous measurements 11 , and while there is no statistical difference in rise if compared to vertebrate actin filaments (rise 27.5 Å, twist −166.6°), there is a statistically highly significant 0.6° difference in twist ( p- value < 10 −15 ).

In the case of pairs corresponding to Cluster II, there was a clear inverse relationship between ω and t , with a highly significant statistical correlation ( r = -0.9032, P < 10 -15 ).

We found a highly significant correlation between promoter CpG O/E and 3' UTR length (Spearman's ρ = 0.24; P < 10 -15 ), indicating that the negative correlation pattern between promoter region methylation and number of miRNA target sites still holds in mice.

Student's t-test analyses show highly significant differences in the overlap of p12 with chromosomes between mitotic and interphasic cells for the 1xMycR virus (p<10 −15 ); similarly highly significant differences in the overlap were observed amongst the 1xMycR or 1xMycR/PM14 viruses in mitotic cells (p<10 −17 ); and an absence of such differences for either the two viruses in interphasic cells or for the 1xMycR/PM14 in mitotic and interphasic cells (p>0.4).

The differences of the expression distributions between bound and unbound genes for all the transcription factors under study are highly significant (p-value<1e-15).

This result was consistent across feature levels and parameter settings, and is highly significant for all tests: that is, for every comparison between modular subnetwork features and gene features, we have P < 10 -15 .

Notably, the PluriUp gene module contains 86% of the PluriNet genes (Figure 6B ), a highly significant overlap by Fisher's exact test (p < 10 -15 , Additional file 3 , Table S6).

Interchromosomal locus-locus contacts The interchromosomal contact frequencies in the structure population are correlated with those observed in experiments, with an average Pearson's correlation of 0.54, which is highly significant ( P < 10 −15 ) ( Fig. 3E,F ; Supplemental Fig. 2D).

We observed a highly significant correlation between the log transformed mRNA half-lives of the two organisms (Pearson r = 0.51, P < 10 -15 ; Figure 2c ), although many genes displayed differential half-lives.

Similarly, we found slightly reduced but still highly significant correlations using expression differences normalized to the average variation (effect size) (Pearson's correlation R = 0.566, p < 10 -15 and R = 0.584, p < 10 -15 , respectively).

Of the 197 DM loci between L-iPSCs and F-iPSCs, 133 loci were also DM between LCLs and fibroblasts (a highly significant overlap ; χ 2 test; P < 10 −15 ).

The average correlation coefficient was 0.511 (standard deviation 0.113) which is highly significant ( P <10 −15 ) for the average protein length of 217 residues in the PDB set.