Excerpts

8 A–D, GSTO1 expression is significantly elevated in tumor tissues compared to normal tissues across several datasets (E_MTAB_8588, GSE42743 , and TCGA_HNSC), with highly significant p-values (p < 2.2e–16, p = 7.3e–08, and p < 2.2e–16, respectively).

The excess of GC to AT substitutions is highly significant, indicating non-equilibrium ( p < 2.2 × 1 0 − 16 ).

The results of the statistical linear regression between RSSI and the logarithm of the node-gateway distance (logD) are robust and highly significant (R2 = 0.808, p -value < 2.2 × 10 −16 , residual standard error = 10.68 dBm).

This targeting is highly significant as compared to the targeted human proteome counterpart (exact Fisher test, p value <2,2×10 −16 ).

Analysis of application inflow Davies‘ test for significance of breakpoints resulted in a highly significant change in the slope of the participant inflow ( p -value < 2.2e − 16 ).

Considering the noisy estimates of RNA half-lives, also these modest improvements are remarkable, and statistically highly significant ( p < 2.2 × 10 −16 for all three references, t -test).

4E ) was highly significant ( P < 2.2 × 10 −16 for DHSs and P = 3.9 × 10 −16 for TSSs, Spearman’s rank order correlation).

Flies (Diptera) were captured along all months under study and in all areas of the island ( Fig 10 ), but there were highly significant differences among months (G-test, G = 125.24, d.f. = 9, p = 2.2x10 -16 ).

This revealed a highly significant agreement of the number of events between paired replicates (Supplementary Fig. 2b , Pearson's correlation 0.997, n = 30, two-sided, p value < 2.2e−16), indicating that uvCLAP events capture the amount of pulled down RNA exceptionally well.

This is a highly significant (p < 2.2 × 10 −16 ) excess (see Materials and Methods), suggesting some concordance in signal at the individual gene level.

The concordance score based on the χ 2 -test is highly significant (p < 2.2e-16), and the overall accuracy to clinical types is 71.6%, as measured by rand measure, a metric for the percentage of agreement on a pair of samples belonging to the same group.

This comparison resulted in 196 common antigens out of 481, a highly significant overlap (odds ratio: 6.4088; 95% CI: 5.3011–7.7479; chi 2 p -value < 2.2 × 10 −16 ).

The variance of differences for the genomic GC proportion in humans, mice, and fruit flies respectively is σ ^ n 2 = ( 0.000673 , 0.00055 , 0.00103 ) compared to σ ^ r 2 = ( 0.00469 , 0.00552 , 0.0021 ) for the permuted genome sequence, with the ratios being highly significant in all cases (F-test with p-value p < 2.2 e - 16 ).

Results from Figure 3 showed a highly significant difference in MIC values among the treatments (χ 2 = 270.89, df = 5, p < 2.2 × 10 −16 ), with a very large effect size (ε 2 = 0.85, 95% CI [0.80, 0.89]).

Fisher’s exact test revealed a highly significant association between treatments and inhibition scores at both 24 hpi and 96 hpi ( p < 2.2 × 10 −16 ).

Food Deserts: In stark contrast, the food desert index showed a strong and highly significant positive spatial autocorrelation (I = 0.4563, p < 2.2 × 10 −16 ).

Thus, because there are three possible replacement nucleotides per site, WC sites are ∼66% saturated and nWC sites are ∼90% saturated, and this difference is highly significant ( p <2.20×10 −16 , Binomial test; see Materials and Methods for details).

1c ), which exhibited highly significant hypomethylation ( P < 2.2e-16; Fig. 1d ).

We first assessed the variation in gene expression among the three biological replicate samples for each sex and tissue; the correlation values were highly significant between them all (Spearman's rank correlation coefficients of at least 0.95, p-value<2.2×10 −16 ; Figure S1 ).

A modest, but highly significant, increase in circRNA size was also observed, again consistent with the ESC retinal model ( Fig. 8 C, P <2.2E-16, Jonckheere-Terpstra test).

Moreover, not only do we find differences in predictive performance between populations from different continents, we also find highly significant differences in prediction accuracy among the four European ancestry populations considered ( F -test p -value < 2.2 × 10 −16 ).

Global enrichment analysis identified a significant overrepresentation of nominally significant interactions with vitamin D deficiency ( p < 2.2 × 10 − 16).

Further, the concordance of miRNA expression (log normalized) of the common miRNAs was also explored by Spearman correlation and showed a highly significant correlation with rho of 0.81, p<2.2x10 -16 ( Fig 4b ).

The latter explanation is supported, because there is a highly significant between-haplotype component of variation for the trait ( P < 2.2 × 10 −16 for the whole data set; P between 4.1 × 10 −13 [L14] and 0.022 [L06] for the individual MA lines).

Biological age showed a highly significant Pearson’s correlation with chronological age of 0.98 ( p -value < 2.2e − 16) (Fig. 2 a).