Excerpts

As a result, we found a highly significant positive relationship between visual bleaching scores on Day 0 and Day 7 post-stress ( Fig 3A and S2 Table , linear mixed effects model, p < 2.2e -16 , marginal R 2 = 0.863, df = 44), such that VBS at Day 0 post-stress was highly predictive of VBS throughout the following seven-day period.

Based on paired t -test, we showed that the exponential regression model had highly significant mean R 2 accuracy than each of the existing methods (Holsteins: t = 584.8–37281; p < 2.2–16; Jerseys: 1178.5–5861.4; p < 2.2e-16).

Finally, we observed a highly significant increase (one-sided Student’s t -test, p = 2.2 × 10 −16 ) in average epistasis values in the winning CR genotypes compared with the overall population, indicating that positive epistasis plays an important role in determining the fittest genotypes in this selection (Fig. 5b ).

The enrichment for tryptophan-depletion-induced W>F peptides (44 versus 4) is highly significant, considering the globally reduced protein expression ( P < 2.2 × 10 −16 ; Fig. 2b, d ).

Wilcoxon rank sum test with continuity correction revealed highly significant changes for old versus young cortex and hippocampus circRNA TPM values ( P < 2.2 E-16) ( Fig. 2d ).

All fitted models were highly significant ( F 5,122 = 26.1, p -value < 2.2 × 10 -16 with ‖ Δ ^ ̄ − Δ ‖ as response; F 5,122 = 47.7, p -value < 2.2 × 10 -16 with λ ^ ̄ as response; and F 5,122 = 12.1, p -value = 1.6 × 10 -9 with | ε ^ g e n − ε ̃ g e n | ̄ as response); residual plots showed no large deviations from the assumptions of normality of error distribution (an asymptotic normal distribution of the response variables is warranted by the central limit theorem), homoscedasticity, and independent errors (data not shown).

We observed a highly significant rate of concordance and overlap between cerebellar expression profiles of Atxn1 −/− and Atxn1 154Q /+ mice (z = 11.9485, P -value<2.2e-16, Kendall-τ test).

2 A), which was still highly significant ( p = 2.2e-16) due to the number of data points.

IAPs are specific targets of Dnmt1’s de novo activity Next, we compared the DMR distribution over genomic features and found a highly significant enrichment at LTRs, which is independent of regional CpG density ( P < 2.2 × 10 −16 , Wilcoxon test, DMRs compared with CRs; Fig. 2e and Extended Data Fig. 2b ).

Spearman’s correlation of the methylation levels obtained for the fully methylated and unmethylated HBV controls with Nanopolish and Guppy+Medaka indicated a highly significant correlation ( R =0.83, P <2.2 −16 ) ( Fig. 2e ).

2d and e ) and the Pearson correlation of these DNAm changes is highly significant ( p < 2.2 × 10 −16 ).

Furthermore, a linear model comparing the paired connectivity estimates from the 24-particle and 1-particle-per-day scenarios revealed a highly significant (p < 2.2e-16) and remarkably strong linear relationship, closely approaching a 1:1 correspondence (R-squared = 0.999; Fig. 3 ).

A highly significant correlation (R 2 = 0.94–0.96, P < 2.2e-16) confirmed the accuracy of the 3D scanning method ( Fig.

239.3 cm) compared to Sb, and in both cases differences resulted highly significant ( p = 2.2×10 −16 and p = 2.7×10 −15 for MAT and PH, respectively).

Indeed, pit-diggers performed ~ 15x more CNN-predicted scoops versus spits within daily bower ROIs and this pattern was highly significant within each subject (CV: 273 scoops vs. 20 spits, χ 2 = 311.35, p < 2.2 × 10 –16 ; TI subject 1: 339 scoops vs. 16 spits, χ 2 = 127.2, p < 2.2 × 10 –16 ; TI subject 2: 602 scoops vs. 60 spits, χ 2 = 377.28, p < 2.2 × 10 –16 ).

Direct correlation analysis further revealed that IDO1 expression maintained a strong, highly significant positive correlation with CD8+ T cell infiltration (R=0.64, p =2.2×10 -16 ) ( Figure 3 ).

This correlation was highly significant ( p < 2.2 × 10 −16 ), indicating that the observed similarity is unlikely to occur by chance. 2.4 Expression of PAMPs and DAMPs in Human and Murine pDCs Quantitative proteomic comparison of human and murine plasmacytoid dendritic cells (pDCs) revealed selective, pathway‐specific differences rather than global proteome shifts.

This difference in the proportion of homologous genes between preferentially sporophyte expressed and all expressed genes was highly significant in both species according to a chi-squared test ( P. patens : χ 2 df = 1 = 206.16, p < 2.2 × 10 –16 ; F. hygrometrica : χ 2 df = 1 = 384.73, p < 2.2 × 10 –16 ).

Of the 236 transposable elements detected in our RNA-seq data, 97 are differentially expressed in xct-2 , representing a highly significant enrichment (1-tailed Fisher's exact test, P < 2.2e–16; Fig.

There was, however, a highly significant correlation between change in TE score and GC content (Pearson’s correlation value of −0.1337, p-value<2.2e −16 ) ( Figure 1I ).

The difference was highly significant ( p < 2.2 × 10 −16 ), indicating robust epigenetic dysregulation of the SYTL4 locus in breast cancer ( Figure 2 A).

This difference in size between the three types was highly significant for both length ( F = 328.7, df = 368, p = 2.2e‐16) and weight ( F = 478.2, df = 368, p = 2.0e‐16), with highly significant differentiation between even the closest two types (kokanee and hybrid; length: F = 20.3, df = 301, p = 9.51e‐0; weight: F = 44.61 df = 301 p = 1.16e‐10).

In this study, we found a highly significant correlation between the letter and pseudo-letter versions of the MEP task ( r = 0.73, p < 2.2 × 10 −16 ; CI = 0.710–0.758; dis-attenuated correlation r = 0.915, with task reliability of 0.80).

A focused analysis of the TCGA-STAD cohort confirmed a highly significant and robust positive correlation between SOX9 and TRAIP mRNA levels (Fig. 2 B, right panel, R = 0.427, p < 2.2e-16).

Further, the concordance of miRNA expression (log normalized) of the common miRNAs was also explored by Spearman correlation and showed a highly significant correlation with rho of 0.81, p<2.2x10 -16 ( Fig 4b ).