Excerpts

However, the overlap between the two categories of the intergenic transcribed regions is highly significant (P-value < 10 -16 , chi-square test)." Contributor Information Philipp Kapranov, Email: [email protected].

The difference between the two distributions was highly significant ( p < 10 −16 , two-sided Wilcoxon rank-sum test).

This yielded a PPI with 235 edges with an extremely significant enrichment p -value < 1.0e−16 ( Fig. 10 ).

However, the overlap between the two categories of the interagency transcribed regions is highly significant ( P -value < 10 -16 , chi-square test).

The difference of the average log2-scaled metformin levels in blood between both groups was highly significant ( p < 10 −16 ).

In each of the hippocampus, amygdala, thalamus, caudate, nucleus accumbens, and brainstem, one or more diffusion metrics were highly significant with P < 10 −16 .

This test yielded highly significant results for both similarity types (Functional and Taxonomic) across all three runs (Taxonomic: H-statistic 80.64–107.68.64.68, p < 1e-16; Functional: H-statistic = 380.5–457.7, p < 1e-80), indicating that at least one category distribution differed from all the others.

The regression itself was highly significant ( R 2 = 0.93, P < 10 −16 ), and outliers were those points lying above or below a 99.9% confidence interval around the line of best fit.

In contrast, highly significant differences were observed between promoter usage in ΔCTCF-HPV18 episomes compared to HPV18 following keratinocyte differentiation (p < 1E-16).

We observed a strong (Pearson correlation coefficient of r = 0.98) and highly significant ( p < 10 −16 ) linear relationship between the number of infected individuals N ( t ) and the method’s incidence correlate φ ( t ).

This was again underpinned by the ANOVA analysis, reporting a highly significant influence of the flyer ( p < 10 − 16 ), but only a weak influence of the base ( p ≈ 0.086 ).

In Silangit, the most discriminative metabolites were tromethamine, oxalacetic acid, adenosine, phenylacetaldehyde, and bis(2-ethylhexyl) phthalate, all of which showed highly significant differences ( p < 1.0 × 10 −16 ).

STRING analysis reveals a highly significant clustering ( p = 1 × 10 −16 ) of over 90% of the proteins identified ( Figure 7 ), with the existence of sub-clusters related to ER protein quality control, mitochondria membrane protein translocation, nuclear import, and stress granules.

Protein–protein interaction (PPI) analysis revealed a highly significant network connectivity among these proteins ( p < 1.0 × 10 −16 ).

Figure 4 puts the predicted ratios in the context of the training ratios, and Table S8 of the Supporting Information quantifies their correlations, elucidating a variety of trends: (1) no_resampling shows a positive trend between the training and the predicted ratio (Pearson’s r 95% CI: [0.440, 0.496], p < 10 –16 ), but since the training and the test ratio are also positively correlated ( Figure 3 ), the latter could be the one driving the predicted ratio of positives; (2) resampling_after_clustering had a constant

The network showed highly significant PPI enrichment (p < 1.0 × 10 −16 ), with an average node degree of 3.52 and a local clustering coefficient of 0.497, supporting the presence of a non-random and moderately clustered interaction structure.

Initial mapping using an imputed genotype matrix for 2029 accessions (Togninalli et al ., 2018 ) revealed a highly significant peak associated with symptom score and total SA levels (−log 10 ( P ) = 15.96 and 10.64, respectively) spanning over 10 Kb on Chromosome 2 (Figs 1 , S2 for SA) and one marker reaching significance on Chromosome 3 (−log 10 ( P ) = 7.59) that is only associated with symptom score.

The M3 from the Japanese cohort wholly covered all the genes involved M11 from the TCGA cohort, which is highly significant overlap (n=41, hypergeometric test, P < 1.1e-16, Figure 2 g).

AgeAccelGrim remains a highly significant predictor of lifespan after restricting the analysis to never-smokers (N=3,988, meta analysis P=1.1E-16, Supplementary Fig. 9 ) or to former/current smokers (P=3.5E-33, Supplementary Fig. 3A ).

It was found that the level of significance was highly significant ( P = 1.1102e-16).

Irrespective of clades, all strains treated with 4 wt%Ag/TiZSM-5 zeolite and Ag-silicalite-1-nanomaterial showed highly significant inhibition for both biofilm [(24 h; F = 57.4079 and p = 1.1102 × 10 −16 ) (48 h; F = 43.3833 and p = 1.1 × 10 −16 ) and planktonic C. auris, compared to the control conditions.

The enrichment of SRCAP variants in the Caribbean Hispanic patients with LOAD was highly significant at p = 1.19e-16.

During the active period with lights off there was a highly significant difference between males and females (p = 1.3E-16) and also some difference between sites (p = 1.1E-3) with a significant interaction between site and sex (p = 3E-6) ( Fig 6a and 6b ).

As shown in Table 1 , the pMHCs that induced higher contact areas also induced more rapid initial spreading, although the initial spreading rate displayed only 1.8-fold variation depending on stimulation peptide, but peptide discrimination remained highly significant ( p = 1.3 × 10 −16 ).

This up-regulation was highly significant on meta-analysis (Fisher’s combined P = 1.4 × 10 −16 , Fig. 2C ).