Excerpts

The results revealed that genotypic differences were highly significant (F = 15.97, p < 2e–16), indicating substantial variation among genotypes for the trait under study.

This difference in wing length was highly significant (t = −57.479, p < 2e-16).

found that incorporating more than 2000 PRSs to predict coronary artery disease, the increase in AUC ranged from 0.003 to 0.023 compared to a model without MPS, and the p-value for the increase in AUC were all highly significant ( p < 2e-16) 19 .

Although, the correlation was highly significant ( p < 2e-16), the R2 of only 0.57 shows a low predictive power.

As expected, the PY effect was highly significant (P < 2 × 10 −16 ), and the smoking group W5Y remained significant after correcting for PY (P = 0.008).

The smooth terms for longitude and latitude were highly significant, indicating that both geographical coordinates are important predictors of macroplastic concentration ( p < 2e-16, n = 206 for ScriptR results from GAM test, Supplementary Figure S5.2).

Highly significant associations (log-rank test, P < 2 × 10 –16 ) for all three variables were observed, in the whole series and in the two subsets (Fig. 1 ).

Moreover, the relationship between the two methods of load estimation was highly significant (F 1,72 = 2420, p = 2.2 × 10 −16 ), and the slope was not significantly different from 1 (0.96, 95% CI [0.97, 1.05]), supporting the hypothesis that only Wolbachia w Sc1 and w Sc2 circulate in the S. cleopatrae flea populations.

Based on the comparison of intact to degraded cartilage, the log-fold-changes in RNA expression and the differences in mean promoter region methylation values demonstrated a small but highly significant correlation (Pearson’s r = −0.08, p < 2.2 × 10 −16 , Fig. 2b , Supplementary Table S7 ).

The correlation of the concentrations determined by 1 H-NMR and by quantitative methods were highly significant for both the samples of ccDMEM (Pearson: r = 0.99, p = 2.20 * 10 −16 ) and of vcDMEM (Pearson: r = 0.91, p = 2.84 * 10 −6 ).

Indeed, pit-diggers performed ~ 15x more CNN-predicted scoops versus spits within daily bower ROIs and this pattern was highly significant within each subject (CV: 273 scoops vs. 20 spits, χ 2 = 311.35, p < 2.2 × 10 –16 ; TI subject 1: 339 scoops vs. 16 spits, χ 2 = 127.2, p < 2.2 × 10 –16 ; TI subject 2: 602 scoops vs. 60 spits, χ 2 = 377.28, p < 2.2 × 10 –16 ).

We observed a highly significant effect of humidity (GLMM: p < 2.2e−16, x 2 = 266.93, df = 4; Table 2 B; Fig. 3 ) on T p of adult flies.

The overlap between EgrNAC26-OX and EgrNAC61-OX datasets was highly significant ( P < 2.2 × 10 −16 ), only one transcript was alternately up- or down-regulated across time points, and DEGs common to EgrNAC26-OX and EgrNAC61-OX datasets were all up- or down-regulated concordantly, demonstrating robust and consistent activation of a subset of shared genes.

The difference in heteroplasmy between sexes was highly significant (129/0 males and 570/32 females,Chi-Square test, p- value < 2.2 × 10 −16 ) and corroborates results from a previous study 24 .

Given the large ExAC data sets sampling 60,706 individuals, the differences were extremely significant (p-value < 2.2e-16).

All regressions were highly significant ( p < 2.2 × 10−16).

The final model was highly significant ( p = 2.2e−16), and for all three cancer types IRF1 was identified as a significant explanatory variable for CD274 expression (Table 1 , left 3 columns).

This is a highly significant (p < 2.2 × 10 −16 ) excess (see Materials and Methods), suggesting some concordance in signal at the individual gene level.

S6 , we found a highly significant correlation between amplicon genus abundance PCoA1 and shotgun species abundance PCoA1 (the Spearman’s correlation ρ = 0.881 , p-value < 2.2 × 10 - 16 ).

Out of 387 proteins associated with gestational age in human amniotic fluid, 225 (58%) were also associated with gestational age in rhesus and the correlation of effect sizes between the two species in the 225 overlapping false discovery rate (FDR) significant proteins was highly significant (R = 0.75; p < 2.2e–16; Fig. 4 ).

Further constraining the thresholds led to highly significant misfits for both positive and negative factors (positive factors, Δ χ 2 397.1, Δ DF 116, p < 2.2E-16; negative factors, Δ χ 2 444.5, Δ DF 52, p < 2.2E-16).

Wilcoxon rank sum test with continuity correction revealed highly significant changes for old versus young cortex and hippocampus circRNA TPM values ( P < 2.2 E-16) ( Fig. 2d ).

In this study, highly significant Pearson’s correlations ( p -value = 2.22 × 10 −16 ) among the mRNA expression of these genes were obtained (r ELOVL5-ELOVL6 = 0.90; r ELOVL5-SCD = 0.84; r ELOVL6-SCD = 0.86), supporting the involvement of common elements regulating their mRNA expression.

The markers BTA-76907-no-rs and ARS-BFGL-NGS-110734 had undefined positions on the genome and showed highly significant associations with κ-CN ( P = 2.80E-16) and β-CN ( P = 6.16E-15) (see Supplementary Table S1 ).

The summary data showed that the association with the concurrent presence of the three antibodies was highly significant (Fig. 1C , 3 Ab vs . 0 Ab: OR = 2.00, p = 4.4 ×10 −16 , I 2 = 17%), and significantly stronger than the observed with the patients carrying two antibodies when directly compared (3 Ab vs . 2 Ab: OR = 1.54, 95% CI 1.29–1.84, p = 1.4 ×10 −6 , I 2 = 12%).