Barely Significant

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highly significantp -value < 0.0010.0× alphaqualifiedgold
Similarly, the static water contact angle of chitosan conjugated titanium was highly hydrophilic (39.2 ± 0.6°), while fluorinated conjugated samples containing chitosan displayed hydrophobic contact angles (108.2 ± 5.2°), which dictated a highly significant change ( p -value < 0.001).
highly significantp < 0.0010.0× alphaqualifiedgold
Except for the factor loadings of the first indicator of each latent variable (e.g., PC1, IN1, CU1), which are set to a fixed value of 1.000 to achieve model recognition, the nonstandardized path coefficients of the remaining observed variables are statistically highly significant ( p < 0.001).
an evident trendP ≤ 0 . 0010.0× alphagold
Moreover, there was an evident trend to favour ICIs than control therapies for cancer patients in control group with placebo (OS: HR: 0.64, 95% CI: 0.53–0.77, P ≤ 0 . 001 ; PFS: HR: 0.55, 95% CI: 0.47–0.65; P ≤ 0 . 001 ) and chemotherapy (OS: HR: 0.74, 95% CI: 0.68–0.80, P ≤ 0 . 001 ; PFS: HR: 0.79, 95% CI: 0.69–0.90; P ≤ 0 . 001 ), but not with biologics (OS: HR: 0.93, 95% CI: 0.74–1.16, P = 0 . 496 PFS: HR: 0.97, 95% CI: 0.80–1.17; P = 0 . 730 ).
a significant trendp < 0.0010.0× alphagold
Using a generalized additive mixed model (GAMM 51 ), which accounts for the temporal structure within the data by specifying a correlation structure (corAR1), we test for change in the estimated size of the projected potential climatic niche space through time, from 145 ka to 30 ka ago and find a significant trend ( r 2 = 0.373, edf = 2, p < 0.001), in which as time progresses, there is a general pattern of contraction from the Eemian onwards (Fig. 5 ).