Excerpts

Indeed, when we compared the South African and Canarian goats with the remaining populations, estimated F ST coefficients were moderate (F ST = 0.06–0.14) but highly significant ( P < 1.10 −5 ).

The OPLS-DA model showed a good fit (R 2 = 0.65), predictivity (Q 2 = 0.55) and a highly significant CV-ANOVA ( p value = 1.1E −5 ).

The 4-GES again predicted OS in a highly significant manner (adjusted p = 1.2 * 10 −05 and adjusted p = 5.6 * 10 −05 for cohorts 1 and 2, respectively; Fig. 2A,B ).

random cross-observer comparisons was highly significant (rank sum test; p = 1.4 × 10 −5 ).

Among infected fish we observed a significant reduction in microbial richness (Chao1, P = 0.0136), raised diversity (Shannon, P < 7.86e-06) as well as highly significant destabilisation of microbial community composition (Pairwise Unifrac, beta-diversity, P < 1.86e-05; P = 0.0132) by comparison to controls.

The top result did not reach statistical significance (Bonferroni threshold for number of genes, p-value < 1.93 × 10 −5 ) was with increased predicted expression of ETS variant 4 ( ETV4 ; chromosome 17; p-value = 0.0015).

When the entire sample was evaluated together, the facial asymmetry scores of the scoliosis group were significantly higher than those of the non-scoliosis group, and this difference was statistically highly significant (U = 1848.5; p = 0.00002).

As expected, we see highly significant enrichment of terms related to influenza (Fig. 7 a) including Transport of Virus ( p = 2.0 × 10 −5 ), Influenza Life Cycle ( p = 5.8 × 10 −4 ), and Influenza Infection ( p = 7.7 × 10 −4 ).

Again, a highly significant (p = 2 × 10 −5 ) overlap was observed in kidney cancer.

Increasing the number of marginally significant height SNPs in the estimates of inbreeding coefficients increased the difference with respect to the random SNPs (P < 2 × 10 −5 for top 2,500 SNPs and P < 9 × 10 −8 for top 5,000 SNPs), further providing evidence of height-based assortative mating in the ARIC European cohort (Tables 2 and 3 ).

For the U-87 MG glioblastoma cell line, on which the present study was focused and for which correspondingly more experiments were performed, the enhancement was statistically highly significant ( p = 2 × 10 −5 ).

Effect of seed treatments with bacterial endophytes on OSR yield, growth and disease incidence under commercial field conditions (Poříčí, Czech Republic) Except for a highly significant (P = 0.00002 and P = 0.00033, respectively) reduction of stress symptoms (red discolouration of leaf margins) by both IP and IG inocula in early spring (March 2017; Table 2 ) none of the seed treatments with bacterial endophytes affected growth, yield and diseases of OSR significantly under commercial field conditions.

This in-phase synchronicity was quantified by means of the synchrony index (SI), showing a highly significant difference (P < 0.00002) between PC-BK −/− (0.13 of ±0.04, n = 18) and PC-WT pairs (0.03 ± 0.02, n = 7).

The coastal southern part of Cameroon had the lowest Bd burden with a highly significant decrease of cases over time (odds = 0.4, P -value = 2.5 × 10 –5 , Table 1 ).

Consistently, a drop in dispersion test showed a highly significant decrease of dispersion upon incorporation of mean intraoperative dBP, liquid balance of length of surgery into the regression formula (F statistic 8.3912, p = 0.000028737), while the addition of mean intraoperative MAP had no further significant effect (F statistic 2.989612, p = 0.085425).

This highly significant enrichment of S-aromatic motifs within the low-reactivity group (p-value = 3 × 10 −5 ), allows us to conclude that the involved methionines exhibit a much lower reactivity than their non-interacting counterparts.

Compared to the untreated control, both treatment protocols resulted in a highly significant reduction in viable cell counts (t-test, t (5) = 14.30, p = 0.00003, ***), corresponding to a ~ 4 log10 reduction (Figs. 6 and 7 ).

In particular, CM-CF showed highly significant differences compared with U-CF ( P value = 0.00003), indicating a positive effect of the combination of mercerization and coating on CF stiffness.

4a , the difference between groups was highly significant (Kruskal-Wallis, P = 3.107e-05).

Among the 1509 successfully imputed SNPs in the SNCA locus, the strongest association was with rs2301135 (chr4:90,758,389, p = 5.68 × 10 −5 , OR = 1.40, minor allele C) and remained nearly significant after correction (threshold p < 3.3 × 10 −5 ) using conservative multiple test assumptions of independent SNPs.

Among the 13 genes in which LGD strict variants were detected, only RET displayed nominally significant enrichment for rare damaging variants and passed the burden test ( P = 3.35E-05, FDR = 0.00047, other data not shown).

In the TCGA breast cancer dataset, we found a highly significant enrichment of Rank-1 cis genes among genes with amplification-driven gene dependencies (Fisher test one-sided P-value = 3.53e-5).

Nominally significant associations with PD risk were identified for four SNPs: XRCC6 rs5751129 ( p = 3.55 × 10−5), XRCC4 rs28360071 ( p = 0.0181), NBN rs2735383 ( p = 0.0213) and RAD50 rs17772583 ( p = 0.0411).

1.95 μg/g, respectively; p = 0.00042), and a similar, highly significant elevation was observed for Cu (median 61.68 vs. 38.43 μg/g, respectively; p = 3.81e-5).

In this study, ANOVA of PBD demonstrated that the model was highly significant, as evident from a Fisher’s F -test value of 12.91 with a very low probability value ( p = 0.0000399; Table 2 ).