Barely Significant

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showed a trendP<0.0010.0× alpha
Subgroup analysis showed a trend that reduced PTEN levels were associated with the following factors: depth of invasion (12 studies, 1599 patients; OR = 2.604, 95% CI = 1.554–4.366, P<0.001); lymph node metastasis (18 studies, 2258 patients; OR = 2.484, 95% CI = 1.836–3.360, P<0.001); distant metastasis (9 studies, 1393 patients;
highly significantp <0.0010.0× alphaqualifiedgold
Data were statistically analyzed following Student's t-test with differences considered significant ( p <0.05, *), very significant ( p <0.01, **), highly significant ( p <0.001, ***) or very highly significant ( p <0.0001, ****).
a significant trendP value <0.0010.0× alphagold
Results Antimicrobial susceptibility profiles Cochran-Armitage trend test revealed a significant trend for reduction in the annual prevalence of antimicrobial resistance for Salmonella obtained from 2002–2016 for amoxicillin ( P value 0.001), ampicillin ( P value <0.001), cefoxitin ( P value 0.001), ceftiofur ( P value 0.001), ceftriaxone ( P value 0.001), chloramphenicol ( P value 0.001), gentamicin ( P value <0.001), streptomycin ( P value <0.001), tetracycline ( P value <0.001), and trimethoprim/ sulfamethoxazole ( P value 0.002)(Figs 1 to 4 ).