Unpaired t-tests comparing the seronegative and seropositive populations yielded highly significant p-values (p<0.0001) for both the Immunetics® C6 Lyme ELISATM ( Fig 2A ) and the MicroB-plex Anti-C6/Anti-pepC10 Immunoassay ( Fig 2B ).
Excerpts
Any regional overlap (within 20 kb) of EWAS and GWAS signals of at least marginal significance (defined as P <1.0*10 −4 ) was identified.
Comparison of the hourly mean values of P1 with those of P2 yields a highly significant correlation coefficient (p < 0.0001, n = 24).
ANOVA on the proportion of nymphs that settled and presumably fed on each site (midrib or secondary veins, on upper or lower sides of the leaf) indicated that differences between healthy and LAS-infected leaves were not significant ( F = 0.02, df = 1248, P = 0.88), whereas those among various sites were highly significant ( F = 25.7, df = 3248, P <0.0001).
HCV-uninfected women were highly significant ( P = 0.0001).
Another useful measure of the strength of the relationship is the Spearman rank correlation ρ (rho) and associated P -value for a Mantel test, which was highly significant for the data shown in Fig. 6 (ρ = 0.855, P = 0.0001, Table 2 ).
Methylation level difference was highly significant (p<0.0001) for all CpGs in LINE-1, Alu repeats and in p16, APC SN1, ACIN1 SN1 and SN3, BCL2, CD44, TNFRSF10C.
E2 treatment when compared to DHT treatment in ovariectomized females resulted in activation of Nrf2 that was marginally significant (p-value = 1E-4) (Lane 1).
The PC1 expression model showed a nominally significant relationship with activity in BA 9 (uncorrected p <0.0001); however, this relationship did not withstand multiple testing correction (corrected p = 0.093).
The overall Fst estimate across all loci was 0.373 and was highly significant (P<0.0001).
By an adaption of the binomial test this level of success was highly significant (p<0.0001).
An unpaired t-test revealed a highly significant difference in TL between the two groups ( t 31 = 6.83, p <0.0001, Figs. 1 and 2 ).
The random effects for feed and COM, the zero inflation parameter, and the square root concentration effect were all highly significant (p<0.0001).
After accounting for differences due to strategy, mean age and mean PSA in the meta-regression analysis, the amount of residual heterogeneity between studies was calculated to be 76.0, which is highly significant at the 5% level (QE = 176.8, p<0.0001).
The final model was highly significant (p<0.0001), with goodness of fit test R -square of 0.22 and adjusted R -square of 0.20.
There were highly significant differences between the eight vervet monkey groups for δ 13 C (F 7, 28.2 = 78.9 P<0.0001).
Using the OPSCC TCGA cohort we demonstrated that HPV-associated tumors abundantly overexpress CDKN2A RNA with an average of 34-fold elevation ( Supplementary Table 6 in S1 Table s) that is highly significant (p < 0.0001, S7 Fig B ).
Pedigree-based estimates of the mean inbreeding coefficient, F ped , are available for 17 of the 51 populations and show highly significant and strong correlations with the very long ROH observed, peaking for the sum of ROH >10 Mb ( r = 0.87, p ≤0.0001).
Unpaired Wilcoxon test confirmed this difference was highly significant ( P <0.0001).
There was a significant trend towards an increasing use of VATS over time (χ2 = 41.85, P <0.0001; Figure 2A ).
Relative to central hospitals, patients at hospitals in the most peripheral quartile had significantly higher odds of death, but patients at hospitals in quartile 2 were no different from the reference, and those in quartile 3 were borderline significant for reduced mortality (OR (95% CI): Q1 2.10 (1.76–2.51), p<0.0001; Q2 1.00 (0.87–1.15), p = 0.997; Q3 0.89 (0.79–1.00), p = 0.050; Q4 (reference)).
There was an overall weak, albeit highly significant, correlation between the sCD26 concentration and the DPPIV activity ( r s = 0.35, P = 0.0001, n = 150).
For human genes, highly significant differences were found between G1 and G2 (F = 1.29; p <0.0001), G1 and G3 (F = 1.33; p <0.0001), or G1 and G4 exons (F = 1.33; p <0.0001), while none was found between G2 and G3 (F = 1.04; p = 0.4254), G2 and G4 (F = 1.03; p = 0.4285), or G3 and G4 exons (F = 1.00; p = 0.9243).
Indeed, the genetic differentiation between the American and European continents that was detected by cpSSRs was high ( F ST = 0.369), and highly significant (P <0.0001).
The number of scales did not show significant differences among the four southern phenotypes (diagonal, vertical and longitudinal bars, and stellate spot; GLM: all p>0.4), whereas the difference was highly significant between these four phenotypes and the round spot skin pattern (GLM: t = 11.9, p<0.0001).