Excerpts

Four other nearby (40–60kb away) but uncorrelated (r 2 with rs12418451 < 0.2) SNPs in this region also showed a trend of stronger effects in males than females, though none suggested a statistically significant difference (p-heterogeneity>0.05, Table 3b ).

We also observed a marginally significant association with melanoma in TPCN2 , suggesting a potential male-specific pleiotropic association with both melanoma and prostate cancer.

However, at higher percentages of doubly transformed cells this effect may be significant ( S1 Fig .) and controls must be run to minimize artifacts [ 36 ].

For all the statistical analyses, tests were considered significant when p -values ≤0.01 and marginally significant when between 0.01 and 0.05.

It is assumed that a set of weakly significant markers may altogether contribute to the risk of developing diseases.

However, a weak trend indicated highest expressions of TLR-7 and -9 in the patients that were not medicated ( Fig. 6B and 6C ).

topodiversity shows a strictly close distribution, with a highly significant correlation index (R 2 = 0.824).

We observed a strong trend in expression patterns from these exosomes.

For some chemical groups our data may be inconclusive due to the low numbers of representative compounds, however in the cases of bromo- (20 compounds), chloro- (41 compounds), and methyl- (35 compounds) flavones it may be significant.

melanoleucus ) lack of explanatory variables with strong significance, but both had one variable marginally significant ( Table 2 ).

Compared with wt mice, the number of cholinergic neurons in tg mice showed a mild trend to decrease at 6 m old, yet no significant difference existed between wt and tg mice ( S1 Fig .).

[ 28 ] also observed a decreasing trend following the maximal crosslinking levels in T7 DNA treated with BCNU, CCNU and MeCCNU using a fluorescent assay.

Contact affiliation showed a trend toward a significant correlation with female prolactin levels in each study.

Colonies showed a trend for fewer workers and males, no queen production, reduced number of wax pots, and reduced colony weight compared to controls.

RYGB showed a trend towards enhanced expression of Asbt in Cm limb in both SD and ZDF rats, but this increase did not reach statistic significance ( Table 3 and S4 Fig. ).

A strong phylogenetic clustering of woody species was evident in crystalline and sedimentary environments, with highly significant values of NRI wood and NTI wood for all but one of these sites whereas phylogenetic clustering was weaker or absent in inselbergs (Tables 3 and 4 , Fig. 2b, e ).

There were strong and highly significant opposite-going effects of pre-flowering NO 3 - treatment on grain yield and grain [N].

Similar observations were made for FVC (and with borderline significance for FEV 1 ) in patients with less severe VDD (10–20ng/mL).

For DNA methylation data, we identified highly significant (FDR<0.005) differentially methylated genes in tumor samples compared to normal samples using the Mann-Whitney-Wilcoxon test, including 1445 hypermethylated genes and 1219 hypomethylated genes.

PICP in both the bNW and bPW groups were significantly lower than that in the TW group ( Fig 3A ) and ICTP also has a decreasing trend in the bPW group compared to the TW group ( Fig 3C ), while the serum BALP concentrations among the 4 groups were not significantly different ( Fig 3B ).

A p-value of <0.05 was considered significant, and p < 0.01 was considered highly significant.

Of the 19 questions we included in the final PRE tool, 11 showed statistical significance in separating known invasive from non-invasive species, four were the result of merging two similar questions, where both were significant or near significant (e.g., different methods of vegetative reproduction, various biotic and abiotic propagule dispersal mechanisms), one was the result of merging four similar questions (human-mediated propagule dispersal) that were significant or nearly significant ( S1 Table ).

Similarly, highly significant negative associations were found when the collapsed protein score was compared between G3 and G4/5, G3 and metastatic cancer, and G4/5 and metastatic cancer (all p<0.0001, Table 2 , Fig. 2 ). 5.

In addition, the number of blood platelet in TRF and model groups showed a decreasing trend when compared to the negative control group.

Interestingly, except for female mice, c-myc expression in male mice showed an increasing trend accompanying with increasing doses of TRF.