Excerpts

For patients without BRF2 overexpression, we detected a highly significant inferior overall survival (OS) and Disease-free survival (PFS), respectively, in patients with high MVD compared with patients with low MVD (P = 0.003 for OS and P = 0.001 for PFS, Table 5 ).

The differences in relative frequencies of the seven colors are highly significant (χ 2 = 14.16, P <0.003, d.f. = 6).

In our results, the ready availability of water showed a highly significant relationship with the cost of illness at (p < 0.003).

In the phonemic condition, the independent contribution of Education only approached significance, while the influence of Computer-use persisted [t(176) = 3.04, p < 0.003].

An analysis of covariance with adjustment for age and sex suggested an overall trend across quintiles (adjusted mean ‘g’ = 0.02, 0.14, 0.13, −0.09 and −0.18 respectively; p = 0.003).

However, while pregnancy was associated with a highly significant fall in creatinine and rise in GFR in HbAA women (P<0.003, P<0.0001), neither occurred in HbSS women (P>0.5, P = 0.186 respectively).

All coefficients are highly significant (P<0.003).

The increase was highly significant (from 40% to 80%) for G. mellonella ( P = 0.003), but not statistically significant (from 20% to 30%) for A. orientalis ( P = 0.552).

Comparing their levels of dispersion from 120 minutes onwards using repeated measurements ANOVA gives a highly significant difference (p = 0.003).

The difference in methylation phenotypes between mice that had no past paternal transmission and those that did was highly significant (P<0.003; one-tailed Fisher's exact test).

However, the interaction Assessment Time x Condition was highly significant (F(5,150) = 3.786, p = 0.003, η 2 p = 0.11).

These differences are highly significant (p = 0.003) ( Table 1 and Fig 2 ).

A highly significant, positive correlation of these two parameters was also identified (Pearson correlation coefficient = 0.954; P = 0.003).

The simple Cox regression models revealed a highly significant impact of renal insufficiency (HR: 7.93 [95% CI: 2.56–24.59, P = .003]), age related macular edema (HR: 7.1 [95% CI: 2.58–19.56, P < .001]) and more specifically the age related exudative macular edema (HR: 64.59 [95% CI: 23.47–177.77, P < .001]).

Relative to the baseline summer season, the winter, spring, and fall season regression terms were all found to be highly significant ( P = 0.003, P = 0.0004, P = 0.001, respectively), indicating that season has a significant impact on the number of weekly diagnostic submissions.

Contrasting with this, there was a highly significant interaction between ATB treatment and age for ileal IAP activity (P = 0.003) ( Figure 2 ).

We observed similar results when performing the enrichment analysis for the Segway segmentation track of GM12878 ( S4 Table ): strong enhancers were the most enriched (p < 0.0001); weak enhancers and active promoters did not achieve significance at the Bonferoni threshold (p = 0.0031 and p = 0.0419, respectively).

The overall Φ ST value was highly significant (Φ ST = 0.644, P <0.0033) indicating strong genetic differentiation across all populations of T. newberryi .

The simulation confirmed that an intersection size greater than or equal to 41 is highly significant ( p = 0.0033).

Comparing mice infected with the first isolate (124A) with mice infected with the third (140A), or with the fourth (144), the overall differences in survival were highly significant ( P = 0.0034 and P = 0.0002).

Suppressed expression of BAP1 occurred in 22 GBC cases (46.8%) and showed a strong trend toward a worse median survival time of 13.3 months (95% CI, 17.6–62.6) (p = 0.0034).

This difference is highly significant (p<0.0035) in Fisher’s exact test.

Female teachers tended to give slightly higher grades than usual—an association which is significant in the random forest model (and the alternative linear regression model using weights, as is described S2 Text ), though not quite significant in the linear regression model (p = 0.0035), with a significance level of 0.0005.

The difference between ICCA patients and control individuals was statistically highly significant (p = 0.0036 for ICCA.SRa and p = 0.0001 for ICCA.SRb, Mann-Whitney test; p = 0.0049 for ICCA.SRa and p = 0.0001 for ICCA.SRb, unpaired t-test with Welch's correction).

Using a Fisher’s exact test, it can be calculated that the distribution of proteins with altered versus non-altered protein amounts in the histone group (3 versus 4) was highly significant different from what could be expected among non-histone proteins (41 regulated and 830 non-altered non-histone proteins, p = 0.0036).