Excerpts

With this stringent filter based on minimum absolute number of sampled species and consistently high global taxonomic coverage, the correlations between genetic and species diversity increase and the significance of the main parameters remains nearly significant (Supplementary Table 7 ).

For example, the identification of Y326 phosphorylation in Jukat cells (immortalized human T lymphocyte) may be significant given that immune cell activation is tightly regulated by ubiquitination 104 .

P < 0.05, p < 0.01, and p < 0.001 are defined as significant, moderately significant, and highly significant, respectively.

Material reductions in DAPP, not just the slowing of an increasing trend, is the great challenge that remains to be addressed in China.

This result is consistent with the latest update of the authoritative GBD 2017 6 , 9 , but contrasts with some previous studies which indicated that DAPP showed a decreasing trend after 2013 15 , 21 , 22 (Supplementary Fig. 1 ).

In contrast, an increasing trend is obtained for Ir-III coated surface at the same threshold when H c increases, due to the oxygen quenching effect at the open air.

In the spinal cord, however, after MOG 35–55 stimulation, although not statistically significant, there was a possible trend toward an increase in the IL-17A + and FoxP3 + CD4 + T cells infiltrating the spinal cord in Trp73 −/− mice, a nearly significant increase in the percentage of IFNγ-producing CD4 + cells, and increased CD25 expression (Fig. 6d ), consistent with p73 negatively regulating Il2ra expression (Figs. 3e and 5e ).

Furthermore, none of our lead 814 SNPs were nominally significant in the Neale Lab total energy intake GWAS ( P > 0.05/814).

9a ), and found that patients with PARP inhibitor treatment showed a trend of higher risk of bone fracture, serious bone, or musculoskeletal pain, as well as osteoporosis/osteonecrosis, compared with patients with Physician’s Choice Treatment or Placebo (Supplementary Fig. 9b ).

For both daytime and nighttime, the relative risk (RR) curve showed an increasing trend as temperature increased beyond the MMT.

Moreover, we observed that among the events with concordant changes between both species, there was an enrichment of microexons, with a significant trend toward less inclusion in glioma (Fisher’s test p -values 5.389e–05 for RNA-seq and 5.521e–04 for Ribo-seq) (Fig. 5b ).

Gfat1 TG mice also showed a trend of thicker LV internal diameter (LVID) in systole as compared with those in the control group (Supplementary Fig. 9c ).

In contrast AML blasts within the same host showed no changes in, or a slight trend toward increased proliferation (Fig. 4b , right panel).

In TCGA, all the top 10 deleted genes displayed significantly reduced levels of expression, whereas seven out of the top ten amplified genes showed a trend of increase in expression (although not statistically significant) likely due to the small number of samples harboring gene amplifications in heterogenous pri-PCa cohort (Supplementary Fig. 11a ).

Integration of DMG and DEG datasets showed a trend of differential methylation within genes functioning upstream in the pathway (Fig. 6c ), and a significant proportion (37.3–40.8%) of the 1982 genes that interact with CCA1/TOC1 differentially expressed in msh1 memory (Supplementary Fig. 7b ), reflecting sizeable enrichment.

In general, morphologies n409 and n127 showed a trend for some cells with deep-like traits (firing towards the peak) versus n128 and sup1 (a superficial cell reconstructed in our lab) with more consistent superficial-like firing (around the trough) (Fig. 2g ).

Two other neuroimaging phenotypes showed nominally significant effects on depression, including higher MD in the ATR for MR-Egger (tMD-ATR; β = 0.107, p for MR-Egger = 0.028, p FDR = 0.166; however, the Egger intercept was not significant, p FDR = 0.432, Supplementary Fig. 11 , Supplementary Data 6 and Supplementary Table 3 ) and ICVF in SLF (tICVF-SLF; β = −0.025, p = 0.030, p FDR = 0.179 for IVW).

Numerous highly significant interactions were inferred between mo-Macs and aggressive/metastatic tumor cells involving the activation of TNF, TGF-β, and EGFR signaling pathways in tumor cells; these interactions may induce ERK-MAPK signaling, invasive mesenchymal phenotypes, and tumor growth.

Confirming this, we found a highly significant interaction between group polarization and arrival order in the time taken to reach the stimulus (LMM: estimate = −0.026 ± 0.0032, Kenward–Roger F-test: F 1,1998 = 67.9, P = 3.1 × 10 −16 , Supplementary Table 6 ); in other words, the effect of polarization was dependent on the arrival order.

There was a marginal trend that compensation was overall larger for dichotically presented perturbations applied to vowel compared to consonant acoustics ( F (1, 31) VowelvsConsonant = 3.18, p = 0.08, estimate vowel = 0.39, SE = 0.012, t (36) = 3.33, p = 0.002; estimate fricative = 0.013, SE = 0.012, t (36) = 1.03, p = 0.31).

However, in all cases, the effect on the habitable zone and mechanisms for the change are consistent with those described above, and are likely to be significant for any continental configuration and even for low fractions of land.

As would be predicted if Erg, Ebf1 and Pax5 were components of a co-dependent gene regulatory network, this analysis showed a highly significant correlation in gene expression changes observed with Ebf1 or Pax5 deletion in pre–proB and proB cells and those observed with Erg deletion in pre–proB cells.

Near the future M 7.1 hypocenter, there was a gradual increase in φ to values above 1, while in other regions, φ-values showed low values or a decreasing trend to values of φ ~ 1 or below 1.

The μ ( T ) for the Sb-doped ZrNiSn 1- x Sb x crystals exhibits a decreasing trend with T , similar to the doped polycrystalline samples (Fig. 2a ).

The μ ( T ) of the undoped ZrNiSn single crystal, which by nature does not have grain boundaries, still shows an increasing trend with T .