Excerpts

More genes were identified in the screen with a highly significant impact on CENP-A but with a lower fold difference (listed in Supplementary Data 2 and 3 ).

Of these genes, 24% showed differences at a significance level of p < 0.01 (paired t -test, with ~12 nominally significant genes being expected by chance, FDR = 4%).

1 ) and an additional 7 genes were observed at near-significant levels (0.1 ≤ FDR < 0.25).

We identified multiple genomic regions that were enriched for genes having a highly significant correlation with CD8+ T cell abundance, indicating that CNAs occurring at these genomic regions are driving the associations (Fig. 6b and Supplementary Data 17 ).

The fourth step is to adjust observed mutation counts ( y ) based on functional impact scores for nearly significant elements ( q < 0.25).

We also remind that our results show (pages 3–5) that the impact of behavioural interventions to promote the purchase of energy-efficient appliances (a one-time action) is very small and only marginally significant ( d = −0.036, 95% CI: −0.129 to 0.058).

A clear trend for proximal interactions emerged, highlighted by a diagonal signal dominated by intronic RNA signal (Fig. 3a ) derived from protein-coding genes (Fig. 3b ).

Nevertheless, the restricted effect size on HF did remain similar to our unrestricted analysis and the association remained nominally significant.

Such magnetic field and gate modulation of superconducting Fermi arcs open up a new avenue for the manipulation of Majorana fermions, which might be significant to the topological quantum computation.

For example, the identification of Y326 phosphorylation in Jukat cells (immortalized human T lymphocyte) may be significant given that immune cell activation is tightly regulated by ubiquitination 104 .

P < 0.05, p < 0.01, and p < 0.001 are defined as significant, moderately significant, and highly significant, respectively.

Material reductions in DAPP, not just the slowing of an increasing trend, is the great challenge that remains to be addressed in China.

This result is consistent with the latest update of the authoritative GBD 2017 6 , 9 , but contrasts with some previous studies which indicated that DAPP showed a decreasing trend after 2013 15 , 21 , 22 (Supplementary Fig. 1 ).

In contrast, an increasing trend is obtained for Ir-III coated surface at the same threshold when H c increases, due to the oxygen quenching effect at the open air.

In the spinal cord, however, after MOG 35–55 stimulation, although not statistically significant, there was a possible trend toward an increase in the IL-17A + and FoxP3 + CD4 + T cells infiltrating the spinal cord in Trp73 −/− mice, a nearly significant increase in the percentage of IFNγ-producing CD4 + cells, and increased CD25 expression (Fig. 6d ), consistent with p73 negatively regulating Il2ra expression (Figs. 3e and 5e ).

Furthermore, none of our lead 814 SNPs were nominally significant in the Neale Lab total energy intake GWAS ( P > 0.05/814).

We found a clear trend showing that stronger water-surface interactions give larger diffusion barriers (linearly dependent on ~0.5 water–surface interaction), regardless of whether the surface is metallic, ionic, or covalent.

GWAS analysis of regulatory or functional information enrichment with LD correction (GARFIELD) revealed highly significant 3 to 4-fold enrichment of asthma-associated variants colocalizing to DNase I hypersensitive sites in several tissues with biological relevance to asthma, such as epithelium, lung, and thymus (Fig. 4a ; Supplementary Data 10 ).

In contrast AML blasts within the same host showed no changes in, or a slight trend toward increased proliferation (Fig. 4b , right panel).

In TCGA, all the top 10 deleted genes displayed significantly reduced levels of expression, whereas seven out of the top ten amplified genes showed a trend of increase in expression (although not statistically significant) likely due to the small number of samples harboring gene amplifications in heterogenous pri-PCa cohort (Supplementary Fig. 11a ).

Because most of the Antarctic continental shelf has seen a positive trend in sea-ice extent over 40 years of satellite observations until 2014 28 , 44 , an overall decrease in blue carbon can be expected.

Therefore, although our theory is based on the effective Hamiltonian, the predicted jump of the PET is quite likely to be significant and even the sign change of PET, such as Fig. 2 b, d for the HgTe case, might exist in realistic materials.

Here we present two obviously harmonic components (i.e., 6-year and ~8.6-year terms) existing in observed LOD data on the intradecadal scales, where the 8.6-year signal shows an increasing trend in time domain, which is first found to closely associate with geomagnetic jerks.

Confirming this, we found a highly significant interaction between group polarization and arrival order in the time taken to reach the stimulus (LMM: estimate = −0.026 ± 0.0032, Kenward–Roger F-test: F 1,1998 = 67.9, P = 3.1 × 10 −16 , Supplementary Table 6 ); in other words, the effect of polarization was dependent on the arrival order.

8a ; iWAT and BAT showed a trend toward increased cAMP levels).