No cytotoxic activity of UCART123 was elicited against Daudi cells, while there was a clear trend towards increasing degranulation, cytotoxic activity and IFNγ release by CART cells against AML cell lines with low, medium and high CD123 levels (Supplementary Fig. 3 ).
We found 1136 CpGs associated to BMI (nominally significant), of which 729 (64.1%) show a significant P -value for CRP mediating the effect of BMI effects on DNA methylation, with 213 loci reaching Bonferroni significance ( Supplementary Data 2 , 10 ).
Although scattered, we observe a positive trend in dune-field age ( T ) against area ( A ) (Fig. 2 e), which could imply that dune-field expansion is driven by dune migration 19 , 28 .
GCNT3 shows highly significant support ( q < 0.001) and nearly 100% of models selected this isoform over GCNT2C or GCNT1 (Supplementary Fig. 11 ).
For instance, the formation of the micro-fibrils via lamellae fragmentation is consistent with a lack of a clear trend of crystallite size with DR for DR ≲ 10 (refs. 45 , 49 ).
However, a decreasing trend in FVIII transgene expression has been reported, for reasons that are not fully understood and might be related to the challenge of stably maintaining functional episomal vector genomes reaching up to their packaging limit 6 .
Examination of stomatal phenotypes revealed an interesting trend that myr-tagged BSL proteins strongly suppressed stomatal production, whereas nls-tagged BSL proteins strongly promoted stomatal production (Fig. 3a, c ).
However, both fires and aerosol optical depth (AOD) in the southern Amazon show a decreasing trend in the time period of around 2000–2010 20 , 34 – 36 .
To determine possibly significant sites of AzAt labeling, the dataset was first screened for points that meet the criteria of a mutation rate fold change ≥1.5 and an average mutation count ≥100.
The leukaemia cell frequencies in peripheral blood also showed a decreasing trend but did not reach a significant difference (Supplementary Fig. 3e–g ).
The overall survival rates of the two groups estimated using the Kaplan–Meier method showed that the group with a high frequency of the GPX4 1106616 variant at the transcriptome level (positive ferroptosis gene set enrichment value) showed a trend toward worse clinical outcomes compared to the group with a low frequency of the variant (Supplementary Fig. 10 ).
Analyses of Gene Set Enrichment (GSEA) showed highly significant modulations of gene signatures related to cell-cell adhesion, cell-matrix contact, and cell migration in conditioned media conditions compared to control (Fig. 3d, e and Supplementary Fig. 4g, h ).
Even in instances of nominally significant proteins that moderately exceed chance expectations by estimated FDR, the top proteins may still contain molecular information representing real biological differences.
7c, d ), although cell distribution was altered, increased in bins 1 and 2, and a clear trend for less cells was observed from bin 5 (Supplementary Fig. 7c–e ).
Our simulations show that the total CH 4 lifetime in all cases presents an increasing trend, from ~9.5 yr at present-day (2000 – 2019) to ~10.5 yr (RCP6.0) or ~12.5 yr (RCP8.5) by the end of the century (2080–2099) (Fig. 4 ; Methods).
Treatment with deltarasin led to a rapid organoid dissociation and a highly significant reduction in viability of both Apc fl/fl and KPN organoid lines demonstrating an important role for KRAS4B in maintaining CRC organoid viability (Fig. 5 e, f ).
2g–l ), as reported after ablation of PROX1 expression 7 , 23 , 24 , although chemical inhibition of autophagy by CQ showed a trend towards increased expression of CD34 and VEGFR1 (Supplementary Fig. 2g–l ).
We therefore analyzed the phosphorylation levels for all chaperones, and among the 48 chaperones identified in yeast, 43 phosphorylated peptides were detected in 17 chaperones, and phosphorylation levels for 30 of the 43 phosphorylated peptides (69.8%) showed a decreasing trend with increasing specific growth rate.
The Krabbesholm shell midden only has data from one layer within the Mesolithic period for comparison, and the Havnø shell midden exhibits a decreasing trend in age and size of oysters beginning in the Mesolithic period (and with only data for 3 shell midden layers in total across the Mesolithic and Neolithic periods).
Subsequently, an increasing trend in [ 10 Be] reactive and 10 Be/ 9 Be is observed between ~9.8 kyr BP (~111 cmbsf) and ~5.9 kyr BP (~71 cmbsf) suggesting a gradual retreat of the grounding line and the development of a more distal environmental setting (Figs. 2 a, c, 3 a and 4a ).
The quenching degree exhibits an increasing trend with emission energy as in the case of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${I}_{11}^{-}/{I}_{11}$$\end{document} I 11 − / I 11 except for (9, 8) and (12, 5) nanotubes, which do not have a statistically sufficient number of data points (Fig. 3 c, d).
Of note, whereas differences in tumor dissemination between untreated and CT-treated PDO5 in the intra-cecal transplantation experiments were highly significant, we only detected slight differences in the intracardiac assays.
The considerable size of the multi-mode mixing effects on excitonic energy gaps suggest a possibly significant influence on coherent excitonic dynamics.
The lack of a clear trend evidences that the capacity of NO and NO + O 2 adsorption is unable to fully describe the catalytic performance.
Large normalized perturbations, δ n e / n e > 0.1, and electric field fluctuations suggest that anomalous resistivity may be significant.