Excerpts

In our patient cohort, the density of MAGEA4-, UTF1- and PCNA-positive spermatogonia showed a trend to increase with age, however without significance.

Only one cytokine measured, TWEAK, exhibited a significant trend against time from fracture.

A typical BAM file from a single WES experience consumes up to 30 Gb of space, thus storing and analyze data of several patients requires higher computational power and, also storing space, which has clearly significant costs.

Throughout the 12 months of observation, the ECHO group showed a trend toward lower doses, while both the matched control and Ontario groups remained stable at almost the same dose of 66 to 73 mg of MEDs daily.

Compared to the control group, changes of HMGB1 levels in septic shock patients almost reached statistical significance (at the onset of septic shock), but showed a significant increase after 24 and 72 h after septic shock onset ( Table 2 , control vs. septic shock onset: p = 0.08, control vs. septic shock 24 h p = 0.07; septic shock onset vs. septic shock 24 h: p = 0.04; septic shock onset vs. 72 h: p = 0.04).

Although both trials showed a trend towards a better outcome in the active tDCS group, comparison with the sham group showed no significant difference in terms of number of migraine attacks, duration of attacks, and intensity of pain [ 10 , 14 ].

The effect was greater in ECs from MM patients than in those from MGUS patients, although the difference was hardly significant ( Figure 4 E).

The potential implications of this concept may be significant.

However, it shows a slightly significant difference among the groups.

To prevent the exclusion of predictors with borderline significance, a p -value of 0.100 rather than 0.050 was used for the inclusion of variables in the multivariate model.

In DMD patients, a positive trend in improvement of muscle function, as well as other measured physical functions was observed after 48 weeks of ataluren treatment.

Patients that initially presented with DIE showed a trend to also subsequently present with DIE (29/54: 53.7%) at the next surgery.

Statistical significance was set at p < 0.05, while the p value of <0.1 was considered a statistical trend. 2.2.

Fenofibrate did not reduce, but induced an increasing trend in the intracellular lipid content of macrophages.

Similarly, the level of intracellular triglycerides in human macrophages did not decrease in the fenofibrate group, although it showed a trend towards an increase in intracellular triglyceride content in cells treated with fenofibrate ( Figure 2 d,e).

However, our study also suggests the relative plateau phase is relative indeed, as the TTV-levels show a decreasing trend after this first year which continues until a final stable phase develops after 24 months, and that high TTV levels are especially predictive of long-term adverse outcome if samples are taken after 24 months.

Comparing the histological samples of AK in every patient before and after MAL-PDT, we observed a marginally significant increase in VDR expression after the treatment in addition to the already know reduction in P53 and Ki67 expression [ 7 ].

These numbers also show a positive trend towards a prolonged treatment period when compared to other studies, which evaluated historical treatment patterns from 2005 to 2015 in Europe, as well as the US and reported rates between 3 to 22% for third line treatment [ 16 , 26 , 27 ].

Interestingly, in phenotypes C and D, the relationship between FAI and VAT almost reached statistical significance.

LC–ILD histology showed a trend towards fewer adenocarcinomas.

Furthermore, the production of the cytokine IL-6 (an inducer of STAT3) was quantified, which showed a decreasing trend in a time-dependent manner ( Figure 5 A).

A comparison of voriconazole and fluconazole for IFI prophylaxis after HSCT showed a trend towards fewer IFIs in the voriconazole arm, but equivalent overall survival.

They observed an increasing trend of all assessed cytokines from controls to TSCC subjects.

After model correction, taking into account differences in potential UVBE, CONUT index, fat mass and fat-free mass, the odds for 25[OH]D deficiency increased and remained highly significant in subgroups with weight loss (Q4 and Q5), but were also elevated on the border of significance in subgroup with weight gain (Q1) (odds = 2.47; 95% CI: 0.94–6.53, p = 0.06, Table 2 ).

Although both these rod function test results may be explained by test-retest variations, both these tests showed a positive trend.