Excerpts

There was a highly significant difference between men and women in terms of the PRSexDQ-SALSEX total score ( p = 0.000; Figure A1 ), being more serious in female patients. 76.5% felt alteration in their sexual activity after the beginning of methadone treatment, but only 11.8% reported it to the doctor without being questioned.

In our study, this relationship was statistically confirmed, with a highly significant association between obturation density and the presence of periapical lesions ( p = 0.000), supporting existing literature.

The follow-up variable was found to be highly significant and predictive ( p = 0.000) obtaining a beta coefficient = 0.090 (0.079; 0.098), indicating a loss of 0.09 mm insertion level for each month passed.

Regarding justification of the three-level model with a random intercept and a random coefficient, it should be noted that the likelihood-ratio test comparing a random-coefficient model to a random intercept model yielded a highly significant chi-square value of 75.96 (degrees of freedom (DF) = 1, p = 0.000).

They demonstrate, for AKT, mTOR, TSC2, S6K, and FOXO3 expression values, highly significant regression curves (ANOVA p < 0.000) with FMR1 expression, with the linear model being the best fitting one compared to other models.

[ 45 ], in the meta-analysis based on 26 RCTs (2652 women), showed a moderately significant effect of isoflavones on bone loss in estrogen-deficient women (WMD (g/cm 2 ) in LS 0.01 (95% CI: 0.01, 0.02), p < 0.000 and in TH 0.001 (95%: CI 0.00, 0.02), p < 0.01).

The difference remained highly significant and clinically meaningful (9.56 ± 0.56 vs. 7.71 ± 1.63, MD: 1.84, 95% CI: 1.42 to 2.27, p = 0.000).

In women, VO 2 /kg demonstrated a highly significant increase after an 8-week training period on PowerBreathe ( p < 0.000) and remained at the same level after the end of training for a further 6 weeks (Test 3).

For the KOOS-ADL, the ANOVA revealed a highly significant effect of the within-subject factor time point ( p > 0.000; ES: η 2 = 0.20).

Differences between groups in D, H, and W were highly significant (ANOVA, p < 10 −55 ) ( Figure 2 and Figure 3 ).

Kruskal–Wallis omnibus tests indicated highly significant overall group effects for CRP (H = 262.5, df = 3, p < 1 × 10 −55 ), IL-6 (H = 259.5, df = 3, p < 1 × 10 −55 ), and IL-1β (H = 262.1, df = 3, p < 1 × 10 −55 ).

Likewise, wear resistance and marginal integrity exhibited highly significant changes between follow-up periods, especially between T2 and T3 ( p < 10 −32 and p < 10 −38 , respectively).

The model demonstrated a good fit (Pseudo R 2 = 0.4949) and a highly significant overall model effect (Log-Likelihood Ratio [LLR], p = 4.691e-30), supporting the robustness of these predictors.

The association between the two classifications was found to be highly significant (χ 2 = 138.3, p = 6.4 × 10 −29 ).

For a random protein set of comparable size, the expected number of edges was 8, whereas the observed network contained 44 interactions, resulting in a highly significant PPI enrichment p -value < 1.0 × 10 −16 .

The difference between the electrolytic approach (test groups 1, 3, and 5) and PSS (control groups 2, 4, and 6) was statistically extremely significant ( p -value < 2.2 × 10 −16 ).

Welch’s test confirmed a highly significant difference in mean pressure between groups, with higher values observed during intramuscular infusion, mean difference = 0.1430, t = 11.5990, p = 7.22 × 10 −15 , 95% CI: [0.1181, 0.1679].

In paired comparisons of the different materials with the identical surface treatments, all groups showed highly significant differences (groups 1 and 4 p = 3.728 × 10 –11 ; groups 2 and 5 p = 7.721 × 10 –6 ; groups 3 and 6 p = 1.725 × 10 –6 Figure 6 ). 3.2.2.

Using STRINGv11.0 program with the highest confidence interaction score (CIS) of 0.9, processing the 119 genes yielded a protein–protein interaction network of 70 genes, which was found to be highly significant based on hypergeometric test with Benjamini–Hochberg correction ( p = 4.36 × 10 −11 ) ( Figure 2 a).

In the corresponding 2 × 2 analysis, the association between ≥2 organ involvement and systemic disease was highly significant ( p = 2.6 × 10 −10 ), with an effect size of OR 4.72 (95% CI 3.71–5.99).

The test yielded a highly significant result ( p < 0.0000000003), which strongly suggests that this anatomical region is a low-yield zone for metastatic involvement in patients with intermediate- and high-risk PCa.

Our results show a clear trend of increased total lipid levels with the progression of pregnancy (R 2 = 0.78, FDR-adjusted p -value = 8.05 × 10 −9 , Figure 1 ).

The results show also a highly significant p value for vessel diameter in the DCP in SWS patients compared to controls ( p = 0.00000001) ( Table 2 ).

Logistic regression analysis identified operative time as a highly significant independent predictor of flap loss ( p = 2.5 × 10 −8 ).

Results for GWAS were separately described in Table 8 and Table 9 depending on whether p -value was adequately significant ( p < 5 × 10 −8 ) or was situated on the boundary of statistical significance (0.05 < p < 5 × 10 −8 ). 3.