The Gehan–Breslow–Wilcoxon test was highly significant ( p = 0.0065), indicating that survival differences were largely driven by early events.
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AB1 Reduced the Gene Expressions of BRCA1 , BRCA2 , and p53 in MCF10A Cells AB1 resulted in a highly significant reduction in the gene expression levels of BRCA1 (0.25/ p = 0.0069) by 75%, BRCA2 (0.061/ p = 0.0016) by 99.939%, and p53 (0.055/ p = 0.0019) by 99.945% compared to the control of each gene as represented in Figure 9 A. 2.6.2.
In contrast, a highly significant decrease in volumes was observed in cohort B (before vs. after AcPSMA RLT): the mean Volume-SG was 50 ± 13 mL vs. 40 ± 11 mL ( p = 0.007, Figure 1 B).
By contrast, HPV infection resulted in a highly significant suppression ( p = 0.0076) of MMP-3 expression on intratumoral TILs (median IRS of 1.5 vs. 3.0), while the expression on peritumoral TILs remained unchanged.
There was a significant trend in the association between the A allele of rs10838524 and rapid cycling ( p = 0.0076) and this allele increased the risk for rapid cycling both in a homozygote and a heterozygote form (that is dominant model) compared to controls.
+ Vitamin D Tier (Full VDIBS): AUC 0.78 (95% CI 0.73–0.81) ○ Incremental benefit: ΔAUC = +0.05 (95% CI +0.02 to +0.08, p = 0.004); ○ Likelihood ratio test: χ 2 (1 df) = 8.4, p = 0.004 (highly significant); ○ Net Reclassification Improvement: NRI = 0.12 ( p = 0.008); ○ Integrated Discrimination Improvement: IDI = 4.2% ( p = 0.012).
Peak SpO 2 fell within normal values for all groups, although a significant trend in progressive reduction was found between groups (97.7 ± 1.1% vs 97.6 ± 1.2% vs 96.8 ± 1.7% among ND, ERA and LSRA patients, respectively; p = 0.008).
Interestingly, the correlation was highly significant in LN-positive patients ( n = 1133, p = 0.008), and stronger than in LN-negative patients ( n = 2020, p = 0.041).
Regarding non-conjugated steroids, a highly significant trend towards lower values was observed (3/29/17, p = 0.008).
did not achieve significancep = 0.0081
Relative to treatment with 130 Hz, these reductions translate to a further reduction in U87 (15% and 20%, respectively, however did not achieve significance) and KNS42 (19%, p = 0.0081 and 32%, p ≤ 0.0001) ( Figure 2 B).
In fact, between 8–30 weeks, the curve of the body-weight kinetics of aP2-ALOX15 mice was consistently below the curve of the wildtype controls, and this difference was statistically highly significant (Wilcoxon test, p < 0.0085).
However, TUBB qPCR results cannot be confirmed by RNAseq results, but TUBB is in RNAseq nominally significant between 1P and 31P ( p = 0.009).
Effects of Curcumin on aCSK A highly significant decrease in SMA expression was seen when comparing curcumin 20 μM and 50 μM + TGF-β1 to control + TGF-β1 ( p = 0.009 and p = 0.002, Table 1 , Figure 3 ).
showed a trendp = 0.009
However, the associations of these molar ratios with EDSS in patients showed a trend towards negative correlations (0/16/7, p = 0.009), and these associations with T25FWT showed a borderline tendency towards negative correlations as well (1/16/6, p = 0.061).
On the other hand, RSV induced a highly significant rise of TP53 gene expression in FaDu cells, compared to normal HaCaT cells ( p < 0.009, **) and PE/CA-PJ49 tumor cells ( p < 0.05, *) ( Figure 2 A, Table 3 ).
K + -Selective MGCs Among the two-pore domain K + channels, Traak (K2P4.1) displayed a highly significant change, increasing by 239.5% ( p = 0.0092).
The difference in Delta Ct (Ct GOI -Ct REF , in which Ct is cycle threshold, GOI is gene of interest, REF is reference gene) median values between PRODH protein-positive and PRODH-negative cases was highly significant ( p -value = 0.0099, ANOVA test), suggesting concordance between protein and transcript levels ( Figure 1 B).
Statistical Analysis SPSS 17.0 (IBM Corp., Armonk, NY, USA) software was used for data analysis, Duncan’s test was used to test significance (‘*’ represent p < 0.05, significant; ‘**’ represent p < 0.01, highly significant).
After 14 days from starting treatment statistical significant differences in OTA content were recorded: significant ( P < 0.05) for GSE and highly significant ( P < 0.01) for GPE at the 500 and 1000 ppm level, but non-significant changes ( P > 0.1) at 2500 ppm.
The effects were considered significant at p < 0.05 and highly significant at p < 0.01.
The t -test of the above mentioned three parameters shows an extremely significant difference ( p < 0.01) between the two groups.
All data were expressed as mean ± SD and analysed using One-way ANOVA followed by Tukey’s multiple range tests, Dunnett’ s T tests and Student’s T-tests (SPSS Statistics 18.0) to estimate the statistical differences of mean levels among the groups with statistically significant at p < 0.05 and extremely significant at p < 0.01.
Furthermore, these differences became highly significant by day 16 ( p < 0.01).
Most of the models were highly significant ( p ≤ 0.01), except for the models of OH· (Y 6 ) and cell viability (Y 7 ), which were significant with a confidence interval of 95% ( p ≤ 0.05).
Histomorphometrical measurement illustrated a significantly decreased bone area due to EAO (0.361 ± 0.020 mm 2 ) and nearly significant reduction in the adjuvant group (Adj; 0.453 ± 0.043 mm 2 ) compared to the control group (Cont; 0.594 ± 0.048 mm 2 , p < 0.01 vs.