Excerpts

We did, however, observe a subtle but significant skew within the effector T cell compartment: CD70 low dendritic cells favored the generation of effector memory T cells (TEM), while CD70 high dendritic cells showed a trend towards more terminal effector cells (TEFF) ( Figure 4C ).

Through recent dynamic transcriptome analysis, it was found that the level of ZBP1 in the MIRI model showed an increasing trend.

MMP-2 expression showed a decreasing trend with ASIV, though statistically non-significant.

In the present study, the use of conventional immunosuppressive agents, such as azathioprine and tacrolimus, showed a decreasing trend in the post-2019 group, whereas the use of RTX increased significantly ( Supplementary Table 5 ).

Furthermore, their subgroup analysis revealed a notable trend wherein patients with L858R mutations appeared to derive greater PFS benefit from the four-drug regimen compared with those harboring 19-del mutations.

We observed a clear trend towards superior cytotoxicity of CAR-CIK cells compared to CAR-T cells, as well as dose-dependent increased efficacy at higher E:T ratios ( Figures 2D, E ).

Although other cytokines including GM-CSF, IL-12 (p40), IL-2, and IL-17 showed an increasing trend in HFD-fed siglec-E KO mice compared to the WT mice, the increase was non-significant ( Figure 6A ).

The frequencies of pulmonary MZB (B220+ CD93+ CD1d hi CD23 lo ) and their precursor (MZP; B220+ CD93+ CD1d hi CD23 hi ) cells increased significantly in the BCG+BAFF cohort and showed a trend toward increase in the BCG+APRIL cohort compared to the BCG-only cohort ( Figure 2B , Lungs).

At DPC10, there was an increasing trend in IFN-γ gene expression in mChitosan (OMP+FLA)/FLA-NP, mChitosan (OMP+FLA)/FLA-NP WCL 10 and 50 μg/dose, mChitosan (OMP+FLA)/FLA-NP GMP 50 μg/dose, and commercial vaccine groups compared to the mock and mock challenge groups ( Figures 5G, H ).

The frequency of B cells (CD3 - BU1 + ) increased numerically in mChitosan (OMP+FLA)/FLA-NP WCL 2.5, 10, and 50 μg/dose and GMP 2.5 μg/dose and without any adjuvant vaccinated groups at DPC4 ( Figures 6A, B ), which was in a decreasing trend in all of those vaccinated groups by DPC10 ( Figures 6C, D ).

Interestingly, c-Met, one of the targets of TAVO412, which was supposed to be a positive predictor, showed a trend of negatively predicting the response, although the association between gene expression and eGR ratio was not significant ( Figure 3D ).

Comparison of the relative expression levels of the transcription factors; STAT-1 and IRF-5 (M1 macrophages) and STAT-6 and c-Maf (M2 Macrophages), between PM-positive and PM-negative placentas showed a trend toward lower expression for both M1- and M2-macrophage associated factors in infected placentas, with only statistical significance in the levels of STAT-6 expression.

In the univariate analysis, we identified NDMM diagnosis compared to MGUS (p < 0.001), ISS stage II and III (p = 0.002), ECOG ≥ 2 (p < 0.001), and therapeutic intervention (p < 0.001) as highly significant clinical parameters.

Notably, IGHJ-6 usage showed a trend towards being increased in ME/CFSmm patients, but was not statistically significant ( p corrected = 0.11, Figure 2F ).

In contrast, the progression-free survival (PFS) difference showed borderline significance ( 30 ).

The low number of events in the graft loss model is a limitation, although the findings are highly significant.

After ART, the proportion of CD4 + Temra cells continued to show a positive correlation with CD4 + T-cell counts after ART ( Figure 6G ) and exhibited a positive trend with ΔCD4, although this trend did not achieve statistical significance ( Figure 6H ).

RUNX3 and TBX21 also showed a trend toward higher expression in DP cells ( Supplementary Figures 2H-M ).

PFKFB3 , Supplementary Table S3 ), but the z-scores were rather low and lacked a clear trend ( Supplementary Table S4 ).

Anakinra was found to have a positive effect on systemic inflammation, and NT-proBNP showed a positive trend following anakinra.

For patients who achieved CRc after one cycle of CACAG-VEN, MRD-negative patients showed a trend of decreased CIR compared to MRD-positive patients, albeit with non-significant statistical differences between the groups.

The proportion of resting memory CD4 T cells showed a highly significant correlation with all three key genes and was reduced in KOA synovial tissue.

A two-sided p-value ≤0.05 was considered as statistically significant, while a p-value ≤ 0.1 was considered borderline significant.

excrementihominis and DM status, and taking high abundance-non DM as reference, there was a decreasing trend of NAb level at day 180 (p-trend=0.022, Supplementary Table 4 ).

Her2 (369) -A2 complex level for untreated cells showed a trend with tumor cell lysis, although the relationship was not statistically significant.