Excerpts

Overall it seems that in acute COVID-19 infection there is a trend toward a decreased TIGIT frequency on T cells compared to healthy donors while T cells in acute malaria patients generally showed a trend toward higher TIGIT frequencies compared to healthy individuals.

RvE1 Treatment Improved the Host Immune Response to Polymicrobial Sepsis Analysis of peritoneal exudates by flow cytometry ( Figure 3A ) showed a trend for increased (although not significant) peritoneal myeloid cells at 24 h post-CLP in RvE1-treated CLP mice compared to CLP mice with vehicle administration (CLP + vehicle: 2.79 ± 1.80 (×10 6 ) vs.

In fact, the main result was marginally significant.

Moreover, additional proinflammatory molecules showed a trend for upregulation ( Supplementary Figure 3 ).

Overall, there was a strong trend toward fewer deaths when compared to placebo control.

OND patients without anti-HHV-6A/B IgG in CSF or absence of intrathecal antibody synthesis showed a trend to have a higher prevalence of hhv6b-miR-Ro6-2 and −3-5p than positive patients.

They reported that triglyceride and aortic cholesterol mass, and aortic lipid peroxides, have a decreasing trend following supplementation ( 242 ).

Upon LPS stimulation, these cells showed a trend to produce higher amounts of TNF and IL-10, but they were less efficient in inducing T cell proliferation induced by allogeneic leukocytes.

Likewise, GAS induced a significant increase in lipoxygenase catalyzed conversion to hydroxyeicosatrienoic acids (HETEs) and in particular 15-HETE, while the increase in 5-HETE did not quite reach statistical significance.

Flow cytometric analysis of blood immune cells demonstrated a significant decrease in CSF1R + monocytes after CSF1R antibody treatment, which, although a slight trend toward a reduction in cell number can be observed, was not significant after IL-34 antibody administration ( Figure 2E , for gating strategy see Supplementary Figure 1 ).

( 12 ) reported that patients with severe COVID-19 had a highly significant increase in SARS-CoV-2-specific IgA and IgG serum titers depending on the duration of symptom onset, and regardless of patient age and comorbidities.

While we did not perform individual treatment controls in these experiments due to restricted numbers of available CD89 Tg animals, our previous work ( 10 ) and results from Figure 5 (below) showed that while IFN-γ; showed a trend toward protection, it alone was not sufficient to induce a statistically significant lung CFU reduction in any of our experiments.

However, the combined treatment with anti-PD-1 and α-GalCer had synergistic effects, resulting in highly significant reduction of polyp numbers in the small and large intestine.

In this context, it may be significant that the SHP2 (and SHP1) must be bound to their receptors to derepress phosphatase activity, while SHIP1 does not.

When stratified by dosage groups, strong statistically significant (p<0.0001) positive correlations were found between the IgG and NAb titers for all dosage groups ( Figure 5 ), whereas only girls in the 0-dose group had a moderately significant positive correlation between the IgM and NAb titers ( Figure 6 ).

However, the analysis of IFNγ, a product of the adaptive immune response (CD4 and CD8 T cells), showed a trend toward reduced expression in immunized IL-6 KO mice after the lethal infection with influenza virus ( Figure 5E ).

Likewise, sulforaphane treatment of freshly isolated blood mDCs demonstrated a significant reduction of B7-H1 and a strong trend for downregulation of CD80 and CD83 regulatory molecules, although these differences did not achieve statistical significance ( Figure S1B ).

Creatinine levels were downmodulated in EAE mice; treatment started on day 1 normalized its levels and treatment started on day 7 showed a trend to normalization ( Figure 2I ).

However, LR-subjects showed a trend toward a lower frequency of shedding monocytes whereas toward higher level of expression of CD16 in different monocyte subsets ( Figure 2A ).

This same study also showed a trend to higher numbers of Tregs co-expressing the canonical IL-17 transcription factor RORγt, again suggesting a shift to Th17 type immunity in the context of histological chorioamnionitis ( 43 ).

However, a significantly decreased percentage of Tregs was found in SD group ( P = 0.03, n = 20) compared with HC; while in LD, it showed a trend towards normalization.

While it does not reach a statistical significance, a significant trend was observed between FZD9 expression and tumor grade.

Only FR-8, containing a ratio of 60:40 PG: lysyl-PG, showed a trend for CD1d-restriction, whereas FR-9 induced IFN-γ production completely independent of CD1d.

While the main Th1 cytokine, IFN γ , showed significant increases in keloid lesions (P<0.01), IL-17A, the Th17 cytokine, only showed a trend for increased expression in both lesional and non-lesional versus normal skin ( Figure 2 ).

While the trajectories of C1q chain B and C demonstrated a similar increase, only C1qB was significantly increased at DOL7 with C1qC at near significance levels (p-value 0.026, q-value 0.060).