Excerpts

However, after 16 weeks of co-administration of the drugs, blood glucose of mice was significantly reduced ( p < 0.01, p < 0.05), and blood glucose of the Met group showed a significant trend of reduction ( p < 0.001) ( Figure 1C ); the administration did not affect the body weight of db/db mice ( Figure 1D ).

Both MPLA and Pam2 have a highly significant positive trend between number of agonists and TNFα intensity ( p < 10 –3 ) and reasonable R 2 values for the curve fit given the degree of biological variability inherent in an immune response ( Table 1 ).

The results showed that 14 proteins were highly related to SARS-CoV-2 infection, and 12 proteins were further screened with highly significant levels (p < 0.001) that were closely related to hospitalization outcomes; among them, the proteins ADM, IL-6, MCP-3, TRAIL-R2, and PD-L1 can be used as predictors of death.

Consistently, DIRAS3 and FOSB showed a trend of downregulation in MM patients relative to normal subjects (P < 0.001), whereas the other genes showed the opposite trend (P < 0.001) ( Figure 12 ). 4.

As shown in Supplementary Figure S7 , the risk score remained a highly significant and independent prognostic factor (HR = 7.183, 95% CI: 2.852–18.092, P< 0.001) even after adjusting for overall immune infiltration intensity.

The results show that serum CHI3L1 levels were significantly elevated in lymphoma patients compared to healthy controls, with a highly significant difference (P < 0.001) ( Figure 2A ).

With regards to age, there was a significant trend of higher total IgG levels in older children within the patient cohort (median of 4.90 g/L for 0–3-year-olds vs 7.15 g/L for 4–10-year-olds, p < 0.001 and vs 7.90 g/L for 11–18-year-olds, p < 0.0001, Figure 2A ).

A P -value of < 0.05 was considered significant ( * ), P < 0.01 highly significant ( ** ) and P < 0.001 ( *** ).

Principal coordinate analysis (PCoA) based on Bray-Curtis distances showed a significant separation in microbial community structure between the three groups of mice (R 2 = 0.2055, P =0.002, Figure 3A ), with a highly significant separation in the C. jejuni group compared to the Control group (R 2 = 0.2275, P =0.001, Figure S1D ), and in the FMT group (R 2 = 0.1525, P =0.03, Figure S1E ) and the microbial community structure of the FMT group was not significantly separated compared to the Control group (R 2 = 0.1059, P =0.127, Figure S1F ), thus indicating that the FMT preparation worked to regulate the structure of the intestinal flora that had been altered by the influence of C. jejuni and to restore it to normal.

GSEM analysis revealed a significant positive effect of the homozygous wt (A/A) genotype on PTX-3 serum levels (standardized path coefficient of β = 0.259, p = 0.0300) and a highly significant effect of PTX-3 serum levels on disease severity (β = 0.468, (p < 0.0010; Figure 5B ).

In contrast, the antibody levels in the rVacJ and rOmpH groups were higher than those in the killed vaccine group, and the difference was highly significant (p<0.001) ( Figure 2A ).

Overall there was a highly significant increase in OCR from Treg cells in the presence of palmitate-BSA vs. the control BSA ( p < 0.001), while there was a lesser increase in OCR from Tconv cells in the presence of palmitate vs.

Furthermore, immune infiltration analyses showed that 8 types of immune cell infiltration showed highly significant differences between the two risk groups ( p < 0.001).

Therapeutic treatment with INI-2004 led to a highly significant (p ≤ 0.001) reduction in lung eosinophil influx across both INI-2004 doses and treatment cohorts ( Figure 3 ).

We further stratified patients into HRG&LRG, revealing a highly significant survival disparity between the two groups (P < 0.001) ( Figures 5A, B ).

TEFS remained a highly significant independent predictor of OS (Hazard Ratio (HR) = 19.28, 95% confidence interval (CI): 11.11–33.45; p < 0.001) ( Figure 6d ), providing a quantifiable, biology-informed metric for risk stratification.

Differences are considered statistically significant for P values <0.05 and highly significant for P values <0.001.

The difference between the groups was highly significant (P < 0.001; Figure 1C ).

term infant) remained a highly significant predictor of LogCRP (β = 0.455, 95% CI: 0.281 ~ 0.629, P < 0.001).

The disruption of the BBB was pronounced and highly significant as the duration of the treatment increased (380.9 ± 5.4 and 345.7 ± 5.1 AU, respectively, for CS and CC-Tat at the 10 h time point, p < 0.001).

Statistical significance was defined as ‘not significant’ (p>0.10), ‘borderline significant’ (*p<0.1), ‘significant’ (**p<0.05), ‘very significant’ (***p<0.01), or ‘highly significant’ (****p<0.001).

Similar results were obtained for the whole-plaque cohort (stable and unstable plaque), where CCR6 showed a highly significant (P = 0.001) correlation with CCL18 levels (data not shown) when taking all plaques.

Importantly, there was a highly significant correlation between the number of Tfh cells and the number of IgA + B cells in TI biopsies (Figure 3 E; Spearman’s rho = 0.89; p < 0.001).

Similarly, at the genus level, Bacteroides , Prevotella , and Parabacteroides showed highly significant differences (P< 0.001) ( Figure 3I ).

Differences were considered as statistically significant with p ≤ 0.05 (*), very significant with p ≤ 0.01 (**), and extremely significant with p ≤ 0.001 (***) or marked as non-significant (ns).