Excerpts

The difference was extremely significant ( p = 7E −202 ).

The ANOVA statistical difference between the expression levels of the HLA loci was highly significant ( P < 1.0 × 10 −100 ).

Results Monocyte responsiveness to LPS showed a highly significant, negative correlation with blood pressure levels (ρ< -0.4; P<10 -80 ).

In comparative ATAC-seq analyses, the accessibility difference between Aire+/+ and Aire-/- mTEC hi cells at super-enhancers was highly significant (P = 6.6 x 10 -52 ) ( 6 ).

there was a highly significant correlation between measurements of macrophage infiltration and SAMD9 expression in LGG ( Figure 7C ) (partial.cor = 0.551, p = 7.78E-39).

GO enrichments for the lightgreen module are highly significant for “secretory granule” (p=2.14E-38), “secretory vesicle” (p=1.96E-36), and different specific neutrophils-associated terms such as “neutrophil activation involved in immune response” (p=1.04E-35), “neutrophil degranulation” (p=1.04E-35), “neutrophil activation” (p=2.00E-35), and “neutrophil mediated immunity” (p=2.64E-35).

Discussion Our GWAS across two cohorts of smallpox vaccine recipients, totaling just over 1,600 individuals, identified a highly significant (p < 1 x 10 −30 ) association signal from a region on chromosome 5 that was linked to significant inter-individual variations in IFNα response to in vitro stimulation with vaccinia virus.

Survival analysis confirmed the highly significant impact of IL-6 (P = 8.56e−23) on the survival of COVID-19 patients and also identified a nominally significant effect of IL-2R on survival (P = 0.0003, Figure S1 , Table S1 ).

In Cluster 1, the most highly significant GO term was cellular nitrogen compound metabolic process ( p -value= 9.44E-20), followed by small molecule metabolic process ( p -value= 8.68E-15) and biosynthetic process ( p -value= 9.03E-14).

However, while the difference between term and moderate to late preterm TREC was significant but not meaningful, 108 (70–170) vs 101 (64–164) median TREC ( p = 0.0017), the differences between term and extremely preterm, 49 (29–92), or very preterm, 88 (52–149), were both highly significant ( p = 1E −16 , p = 4E −6 , respectively) and meaningful.

The intersection is statistically highly significant (p < 2 -16 ).

Interestingly, in all tumors FOXP3 expression is highly significant, positively associated to GZMB expression levels ( p -value = 2.0E-16) Adaptive immune response strongly depends on the B cell response.

Remarkably, we observed a highly significant negative correlation between B cell levels and HEUScore among all immune cell subtypes ( r = -0.8857, P < 2.2e-16) ( Figure 5G ).

Scatter plots of the log2FC values for differentially expressed genes in the tetramer+ cells arising in response to each pMHCII-NP type confirmed highly significant correlations among the scRNAseq profiles of the different tetramer specificities (P<10 -15 ; >60% of all the genes in each comparison undergo similar levels of upregulation or downregulation as compared to Tconv cells) ( Figure 2C ).

At 2 hpi, highly significant ρ values of 0.68 ( P < 1.0 × 10 −15 ) and 0.67 ( P < 1.0 × 10 −15 ) were observed for the MAP-infected and control sample groups, respectively.

PD comparisons were highly significant (P < 2 × 10 -11 ).

Although the majority of the findings in these included studies did not reach statistical significance, the overall efficacy assessment indicated that SLIT demonstrated effectiveness in pediatric AR patients (SS: SMD=-0.52, 95%CI=-0.75~-0.29, p = 3.17e-10, I2=0%, Egger’s test: p = 0.74; MS: SMD=-0.24, 95%CI=-0.37~-0.11, p = 0.0356, I2=78.68%, Egger’s test: p = 0.34) ( Figure 6 ).

This assessment revealed highly significant correlations ( R = 0.46–0.74; range, P = 2.5 × 10 −9 to 6.0 × 10 −44 ) between datasets generated by the two methods ( Figure 4 ).

Indeed, there was a highly significant overlap between the proteins that increased during the 3 rd trimester and decreased post-partum (13/33 proteins, odds ratio (OR): 98.9, p=4.85e-09, Fisher’s exact test, Figure 4B ) and, conversely, between the downregulated proteins during the 3 rd trimester and the ones upregulated post-partum (13/44 proteins, OR: 29.9 , p=1.73e-05, Figure 4C ).

In fingolimod-treated patients, the decrease in BAFF-R expression was highly significant in all evaluated B cell subsets (1.77 x 10 -5 ≤ P ≤ 3.42 x 10 -8 ) and most manifest in terms of effect size on transitional B cells ( Figures 2A–D ).

Only SNPs mapped to autosomes with CR > 0.98, minor allele frequencies (MAF) > 0.03, and not in highly significant deviation Hardy–Weinberg equilibrium (P > 10 −7 ) were considered in the analyses.

Only SNPs mapped to the autosomes, with call rates > 0.98, minor allele frequencies > 0.03, and not in a highly significant deviation from the Hardy–Weinberg equilibrium ( P > 10 −7 ), were considered for the analyses.

Signature performance was driven by the highly significant associations of the arginine/WARS ( p = 4.3 × 10 −7 , τ = 0.43), cortisol/SOCS1 ( p = 7.4 × 10 −6 , τ = 0.28) and 5-oxoproline/LAP3 (5.8 × 10 −5 , τ = 0.37) pairs ( Figure S8 ).

Statistical analysis demonstrated a highly significant difference in methylation for all CpGs within top strand as compared to the reverse strand for CD45RA + CD15s − Treg ( p = 6.15E-07), but not for CD45RA − CD15s + Treg ( p = 0.026091).

VitD-dependent DE genes in Teff cells from B6 females exhibited highly significant enrichment ( p = 1.02e−6) within genes downregulated in MS-CIS CD4 cells, while marginal or no enrichment was observed for genes that were upregulated in MS-CIS (Figure 3 E).