Barely Significant

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highly significantP = 0.00050.0× alphaqualifiedgold
A highly significant reduction in interleukins-6 (IL-6) (standardised mean difference (SMD) = 1.32 (95% confidence interval (CI): 0.58, 2.06), Z = 3.48, P = 0.0005), a significant reduction in tumor necrosis factor-alpha (TNF-α) (SMD = 1.29 (95% CI: 0.19, 2.39), Z = 2.30, P = 0.02) but no change in overall C-reactive protein (CRP) (SMD = 0.40 (95% CI: -0.26, 1.07), Z = 1.19, P = 0.23) levels were observed by using the random-effects model.
highly significantp<0.00090.0× alphaqualifiedgold
The striking association with PD-1 inhibitors (RR: 24.84; 95% CI: 16.92-36.48), IFN-α2b (RR: 3.10; 95% CI: 1.53-6.30), and CTLA-4 inhibitors (RR: 32.042; 95% CI: 18.052-56.875) were all highly significant (p<0.0009), highlighting a consistent biological signal.
highly significantp<0.0010.0× alphaqualifiedgold
The results of intergroup comparison using the independent-t-test showed a highly significant (p<0.001) distinction between the control and LLLT groups at different time intervals (baseline and six months after) (Table 1 , Figure 4 ).