The difference was highly significant ( p < 0.001).
Excerpts
Second, according to Figure 10 , a strong and highly significant positive correlation was identified between the number of lymph nodes examined and the number of lymph nodes invaded (rho = 0.65, p < 0.001; Figure 5 ).
In contrast, we examined a highly significant difference between SPT and OPT, comparing AVDG to CG ( p < 0.001) and AVDG to ADG ( p < 0.001), but not for ADG to CG ( p = 0.348).
Differences were considered non-significant (ns) when p > 0.05, significant (*) when p < 0.05, very significant (**) when p < 0.01, and highly significant (***) when p < 0.001.
In both PC-3 and HCT-116 models, there was significantly increased caspase 3/7 activity in the PTEN-deficient cells when compared to PTEN expressing cells 48 h following KU-60019 ( p ≤ 0.05; p ≤ 0.05) or IR ( p ≤ 0.05; p ≤ 0.05) and a highly significant increase following combined KU-60019 + IR treatment ( p ≤ 0.001; p ≤ 0.01). 2.4.
Remarkably, we found that tumor shape features, such as surface volume ratio and least axis length, showed extremely significant differences among the three imaging subtypes in both cohorts ( p -value < 0.001, Figure 3 a,b).
Tumor Subsite Tumor anatomic distribution showed a highly significant difference between NSND and SD patients ( p < 0.001).
Her2 and pHer2 expression levels showed a highly significant correlation as well (Spearman-rho = 0.531; p ≤ 0.001).
Furthermore, also the TNM-categories showed a highly significant correlation with the 5-year OS: a high pT category and positive lymph node (pN) status predicted a worse 5-year OS with high significance ( p < 0.001).
Indeed, when stratifying the patients according to this dichotomous cut-off, the difference was highly significant, p < 0.001 ( Figure 2 D); the median OS for the fit patients (4/16 died, 25%) was not reached, while the median OS for the unfit patients (82/104 died, 78.8%) was 12.1 months (IQR: 6.1–29.0).
The pooled OR from the random-effects model is 1.53, with a 95% CI of 1.107 to 1.945 and a highly significant p -value of <0.001.
Of note, all ICCs were highly significant ( p < 0.001), with correlations ranging from moderate (8’ walk, 0.47), to strong (8’ get-up-and-go, 0.74), to very strong (30 s chair stand, 0.80; sit-and-reach, 0.86; 2 min step test, 0.87; back scratch, 0.90; weight, 0.93; and waist circumference, 0.98).
**, *** in the figures indicate very significant ( p < 0.01) and highly significant ( p < 0.001) statistical differences respectively.
Moreover, a highly significant increased risk of young-onset cancer was observed in the female participants (RR 15.6, 95% CI 4.54, 60.3; p < 0.001) who experienced perinatal exposure to famine.
Furthermore, anal cancer highlighted a Joinpoint with a decreasing trend from 2008 to 2014 (APC = −3.7%, 95% CI = −4.7, −2.8; p < 0.001) and a slightly increasing trend in the period 2014–2018 (APC = 1.3% 95% CI = −0.6, 3.3; p = 0.136).
As shown in Supplemental Table S1B and the corresponding forest plot ( Supplemental Figure S1C ), the signature remained a highly significant independent predictor ( p < 0.001) with a high odds ratio when adjusting for prior systemic therapy, IMDC risk category, and the presence of sarcomatoid or rhabdoid features.
The rs10759931 (KpnI) polymorphism showed a highly significant association with TLR-4 expression ( p < 0.001).
However, the correlation of RGVS with the treatment cycle number was highly significant ( p < 0.001) for the breast cancer cohorts ( Figure 5 c).
Association of TSR with Clinico-Pathological Features There is a highly significant correlation between TSR with luminal ER+ histological tumour type and grade (both p < 0.001), but not for TNBC.
Statistical significance was defined as significant (* p value ≤ 0.05), very significant (** p value ≤ 0.01), and highly significant (*** p value ≤ 0.001). 5.
They found a highly significant difference in both HPV-associated OPSCC DSS (log-rank p < 0.001) and PFS (log-rank p < 0.001), with higher TIL levels linked to longer survival.
The narrow confidence interval and highly significant p -value ( p < 0.001) further support the reliability and clinical relevance of this finding.
Response to rituximab induction was a highly significant predictor of better OS, TTP, and PFS ( p < 0.001).
In the Chi-square test, the OSCC tissue samples showed a highly significant upregulation of CD96 mRNA expression ( p < 0.001) and protein expression ( p = 0.005) compared to the healthy mucosa.
The difference in OS was highly significant, with 14 months (95%CI 11.9–16.0) for patients suffering from infectious complications compared to 24 months (95%CI 20.6–27.4, p < 0.001) ( Figure 2 ).