There is a strong trend of a direct correlation between adenocarcinoma (faceted square) and large cell carcinoma (triangle) and a highly significant inverse correlation with NSLC at the upper end (pentagram) and small cell cancer (rectangle) at the lower end ( Table 3 ).
While the Kaplan–Meier survival curves still demonstrated significantly better overall survival and disease-free survival for the “T3 single” group ( Supplementary Figures S1–S3 ), the difference in cancer-specific survival became less pronounced, although the curves still showed a trend towards better survival in the “T3 single” group.
Finally, one study from China indicated that the tumor content of circulating cfDNA is related to the development of HBV-related HCC and presents an increasing trend during the 4-year period preceding clinical diagnosis of HCC, whereas it is correlated with tumor burden and worse survival [ 22 ].
Adherence to optimal laboratory-based triggers for transfusion (Hb values below 7 g/dL or below 8 g/dL in patients with prior history of Cardiopathy) was 31.5% along the years of the study, with a clear trend towards improvement reaching 69.2% in 2018 and without statistically significant differences among the groups ( p > 0.05).
However, a slight trend can be observed, with patients receiving platinum/taxane-based treatments showing slightly lower recurrence rates compared to those treated with anthracycline-based regimens.
PFS showed a trend in favour of the TFH phenotype but this did not reach significance.
highlighted an increasing trend since 2018 in the use of organ-specific immunosuppressants to minimize steroid use in managing irAEs [ 65 ].
The constructed PPI network for GS 10 patients contained 872 protein nodes and 2905 interactions, with enrichment analysis yielding a highly significant p -value of 1.0 × 10 −16 .
However, when the number of mammograms was considered as a continuous variable, under the assumption of linearity, we found a significant trend in BC risk (OR = 1.04; 95% CI: 1.01–1.06) with an increased risk of 4% by additional exposure.
Although WNT pathway alterations were not statistically significant, they were observed at a higher frequency in H/L patients (8.4%) compared to NHW patients (4.0%, p = 0.08674), suggesting a possible trend that warrants further investigation.
In contrast, WNT pathway alterations in NHW GC patients showed a slight trend toward reduced survival compared to those without alterations ( Figure S1 ).
Similarly, the median TMB was lower in H/L patients (0.865 mutations/Mb, IQR: 0.865–1.73) compared to NHW patients (1.6 mutations/Mb, IQR: 0.9–2.2), with a highly significant p -value of 0.00175.
However, when stratified by etiology, early-onset liver cancer associated with steatotic liver disease has shown an increasing trend [ 6 ].
Among the twelve studies included—nine of which were pooled in meta-analyses—chlorhexidine did not significantly reduce the incidence or severity of mucositis compared to placebo, although a trend toward significance was observed in patients receiving chemotherapy.
However, there was a notable trend toward an increased incidence of ONJ in patients who also received bisphosphonate therapy.
Patients with a higher plasma peak concentration of venetoclax showed a trend toward slightly longer OS. 3.4.
With increasing technical experience, console time exhibited a decreasing trend.
For instance, the interaction term between miR-101-3p and tissue invasiveness (X1 × X3) was highly significant, underscoring the complex interplay between these variables.
If confirmed in a larger set, this may be significant in terms of therapeutic decision-making, as these mutations often predict resistance to standard therapies and may guide the use of targeted or experimental treatments [ 19 , 24 , 33 ].
The current no-mutation and EGFR cohorts had a strong trend to longer OS than the respective historic cohorts.
In two secondary database analyses that monitored inpatient LOS for SUD over time, a decreasing trend was observed [ 25 , 44 ].
In contrast, JAK/STAT pathway alterations in H/L EOCRC patients showed a trend toward worse survival outcomes, though the difference was only borderline significant ( p = 0.073).
Survival analysis revealed borderline significant differences in H/L EOCRC patients, whereas NHW EOCRC patients with no alterations in the JAK/STAT pathway exhibited significant survival differences.
The highly significant p -value (<0.0001) indicates a strong association between JAK/STAT pathway alterations and poorer survival, highlighting its potential prognostic relevance.
Quite significant differences in the threshold levels reported by various papers can be possibly attributed to the character of the tumor microenvironment and the interaction between the tumor and host’s immune system.