Excerpts

In SEER, among those <55 years, incidence increased at a higher rate in women (AAPC = 3.22%, p < 0.01) than men (AAPC = 1.51%, p = 0.03), with non-parallel trends ( p = 0.02), while a decreasing trend was seen in both men (AAPC = −2.16%, p < 0.01) and women (AAPC = −1.37%, p < 0.01) of the ≥55 years group.

They found in a multivariate analysis, laterality becomes highly significant ( p < 0.01) and that right-sided tumors have a worse OS than left-sided tumors (15 vs. 18 months; respectively) [ 39 ].

Densitometric analysis revealed a highly significant delay in colony formation in ITIH5-expressing CCC-5 cells by 38.29 % ( p < 0.01).

A statistically significant difference was considered when p ≤ 0.05 and highly significant p ≤ 0.01.

All the statistical analyses were performed via nonpaired two-tailed t -tests (a p -value < 0.05 was considered significant, and a p -value < 0.01 was considered highly significant).

In the combined model, stage and hydronephrosis emerged as significant clinical factors ( p = 0.03 and p = 0.01, respectively), while the three radiomics features remained highly significant ( p < 0.01).

Other factors associated with PFS (or with nearly significant trends) included the number of positive sentinel nodes ( p < 0.01), mitoses ( p = 0.07), primary presentation ( p = 0.06), and BRAF mutation ( p < 0.01), whereas LVI ( p = 0.1) was not associated with PFS. 3.2.3.

A2B5 quantification by flow cytometry revealed a highly significant increase of A2B5 immunoreactivity in ST8SIA3-overexpressing cells as compared to the control cell line (U251-ST8SIA3: 85.13% ± 2.59%, p < 0.01; U87-ST8SIA3: 82.62% ± 1.86%, p < 0.01) and a drastic reduction of A2B5-positive cells in shST8SIA3 cells (U251-shST8SIA3: 2.7% ± 1.1%, p < 0.01; U87-shST8SIA3: 1.6% ± 0.2%, p < 0.01) ( Figure 1 D,G).

Upon analyzing the outcomes of the two approaches, it was found that significant differences exist between them in all 12 cases ( p < 0.05), with some cases showing highly significant differences ( p < 0.01 or p < 0.001).

A highly significant inhibitory effect ( p ≤ 0.01) on viability was observed for 2.5 μM CBD and for 5.0 μM THC and CBD when applied individually.

Nominally significant genes were identified by p < 0.01 and absolute log 2 fold change > 0.5.

Cluster 10 consisted of 201 cells from both the Lin− and Lin+ cell populations from each patient, with over 1800 genes that were highly significant ( p value ≤ 0.01) ( File S3 ).

Among the genes associated with worse OS, several exhibited a highly significant impact on patients’ OS ( p -value < 0.01).

However, a clear trend was observed: patients who were prescribed more than 8 medications during hospitalization were at significantly higher risk of experiencing at least one DDI ( p < 0.01), emphasizing the importance of polypharmacy monitoring as a clinical risk factor.

The EFS and OS for patients with stage I, II, III, and IV MGCTs showed a decreasing trend, with EFS rates of 95.27%, 93.06%, 73.63%, 70.43% ( p < 0.01) and OS rates of 100%, 93.31%, 87.69%, 84.64% ( p = 0.04), respectively.

The results remained consistent: patients with poor pathological response (ypIIA/IIIA) exhibited significantly higher recurrence risks, and intensified adjuvant IO + Chemo showed a clear trend toward superior EFS ( p = 0.011, Supplementary Figures S1 and S2 ). 3.5.

All four endometrial cell lines demonstrated an enrichment of endometrial cancer heritability in the anchors of promoter-associated loops ( Table 2 ), although the enrichment in Ishikawa loops did not reach statistical significance (Bonferroni threshold, p < 0.0125). 2.3.

Consistent with earlier findings, LOH3 conferred a worse prognosis ( Figure S2C ) ( p = 2.5 × 10 −5 ), and there was a significant trend with chromosomal 8q gain ( p = 0.013) ( Figure S2D ), as reported previously.

We observed an increasing trend in diversity from the HC to CRC ( p = 0.013, compared to HC) ( Figure 2 a).

The Number of CD103+ Lymphocytes Correlates with the Infiltration of CD4+ and CD8+ T-Lymphocytes Correlation analyses indicated a highly significant positive correlation between the densities of intratumoral CD8+ and CD103+ T-lymphocytes (r = 0.380; p = 0.013).

Highly significant differences in the absolute lymphocytes and platelets counts were observed among DTC/−T2DM and DTC/+T2DM patients ( p = 0.015 and p = 0.002).

Moreover, for lymphoid and hematopoietic malignancies, a strong and nearly significant association was observed (HR: 1.72; 95% CI: 1.11–2.67, p = 0.015; Figure 3 ).

Lymphocyte count exhibited a decreasing trend of 20% ( p = 0.015), while neutrophil count, platelet count, and NLR and PLR displayed an opposite trend, with increases of 9%, 11.1%, 19.6%, and 39.1%, respectively ( p = 0.532, p = 0.034, p = 0.009 and p = 0.002, respectively), in the DTC/−T2DM patients following the administration of the recommended dose of 131 I.

Not surprisingly, in the control group, there was a positive trend between the number of Ki67-positive cells and absolute tumor volume in males and females ( p = 0.01727).

The normal-like samples did not stain for GLUT1, HK2, and LDHA, with the differences being significant and near-significant with regard to the LDHA and HK2 expression in the cancer sections (44.9% positivity for LDHA, p = 0.018; 35.5% positivity for HK2, p = 0.050).