Excerpts

The association between hypomethylation and TNBC status was highly significant in African-Americans ( p = 0.006), but not in Caucasians ( p = 0.70).

We observed an increasing trend in uterine-artery sparing RT in the endoscopic approach (R Spearman = 0.812, p = 0.006) and when all studies were evaluated together (R Spearman = 0.560, p = 0.016).

primary tumors showed a clear trend towards a higher LC probability for primary tumors ( p = 0.006).

ASCP was a highly significant prognostic factor for overall survival in univariable regression analysis ( p = 0.007) as well as in multivariable Cox regression analysis (HR 1.303; 95% CI 1.013–1.677; p = 0.039).

Histology had a significant impact on local tumor control ( p = 0.039), showing highly significant differences between patients with prostate cancer and “other” (see patient characteristics, p = 0.007).

High-risk patients had a highly significant shorter median OS compared to low-risk patients (16.6 months (95% CI = 13.2–20.0) vs. 29.8 (95% CI = 21.7–37.9), p -value = 0.007) ( Figure 2 ).

In a planned interim report of the FOxTROT phase III trial presented at ASCO 2020, investigating the efficacy and safety of neoadjuvant chemotherapy in 1053 T3-4, N0-2 colon cancer patients, relapse or persistent disease after two years showed a trend toward improvement at 15.6% for neoadjuvant chemotherapy vs. 19.5% for adjuvant chemotherapy ( p = 0.007) [ 43 ].

In detail, the intensity of tumoral HLA-I HC/β 2 -m surface expression correlated highly significant positively with the density of intra-tumoral CD8 + T cells ( p = 0.008 resp. 0.003), but negatively with the number of CD8 + T cells adjacent to FoxP3 + cells within a radius of 30 μm ( p = 0.009 resp. 0.007) ( Table 5 ).

To eliminate possible discrimination due to outliers, a Spearman’s test was performed, confirming a highly significant correlation with β2M ( p = 0.008), plasma cell percentage ( p = 0.035), C-reactive protein ( p = 0.043), and serum calcium levels ( p = 0.038), as shown in Figure 3 A.

With a highly significant pathological complete response of 49% (versus 23% in AC patients; p = 0.008) and estimated 5-year survival benefit from combination chemoradiotherapy compared to surgery alone (AC: p = 0.049; SCC: p = 0.011), it is evident that this patient subgroup had a major benefit from this therapeutic intervention [ 10 ].

In PC patients with a Gleason score of > 7, the inverse correlation was highly significant between baseline or radiation-induced NPB frequency with TL (r = −0.404; p = 0.008; r = −0.403; p = 0.008, respectively; Figure 3 E,F).

Similarly, a significant trend towards better outcomes was observed with increasing Kawaguchi scores ( p = 0.009), with grade 1 tumors having a 51.7% lower probability of good outcomes compared to grade 3 ( Figure 4 and Figure 5 ).

While overall survival was not different between the groups (HR 0.62; 95% CI 0.36–1.07; p = 0.09; I 2 = 80%;), the subgroup analysis of studies employing plastic stents showed a trend toward better survival in the RFA-treated group (HR 0.42; 95% CI 0.22–0.80; p = 0.009; I 2 = 72%).

When we performed a paired analysis with the corresponding normal tissues, a highly significant difference in H 2 O 2 production was found in BRAF + TERT ( p = 0.009), BRAF only ( p = 0.003), ALL BRAF ( p < 0.0001), RET or RAS mutated ( p = 0.02), and ALL MUT tumors ( p < 0.0001) but not in non-mutated PTCs ( p = 0.12) ( Figure 2 , panel B). 3.3.

A clear trend towards impacted antibody titers was seen with rising age ( r = −0.30; p = 0.0093).

Upon analyzing the outcomes of the two approaches, it was found that significant differences exist between them in all 12 cases ( p < 0.05), with some cases showing highly significant differences ( p < 0.01 or p < 0.001).

They found in a multivariate analysis, laterality becomes highly significant ( p < 0.01) and that right-sided tumors have a worse OS than left-sided tumors (15 vs. 18 months; respectively) [ 39 ].

BT-474.rT3 cells showed a highly significant decrease in proliferation in the trastuzumab and TAK-228 condition (52%) compared to trastuzumab (84%, p -value < 0.01) and TAK-228 (67%, p -value < 0.01).

The survival advantage associated with not having promoter-hypermethylated SFRP1 was highly significant (log-rank test, p < 0.01).

However, a clear trend was observed: patients who were prescribed more than 8 medications during hospitalization were at significantly higher risk of experiencing at least one DDI ( p < 0.01), emphasizing the importance of polypharmacy monitoring as a clinical risk factor.

The Kruskal–Wallis Test with Bonferroni correction identified nine of our 754 miRNAs tested to correlate significantly with our VEGF expression and for PTEN, we could find 11 miRNAs with this approach ( Table 4 ) which is a highly significant overrepresentation of miRNAs identified ( p <0.01).

Of the nominally significant modules, lightsteelblue (r = 0.63, p = 0.01) and darkviolet (r = −0.57, p = 0.03) were of the most interest.

Three variables were highly significant ( p < 0.01) in the final averaged multiple imputation model as well as in each of the 10 individual imputed datasets: MR-proADM, ST2 and tumor stage.

When stratified by type, there was a decreasing trend for melanoma in both men and women (males: −6.4, p = 0.01; females: −4.3, p = 0.032).

Statistical differences were defined as significant for * p < 0.05 and highly significant for ** p < 0.01 and *** p < 0.001. 3.