High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations.

We observed marginally significant changes for sperm motility (49 ± 3% vs. 38 ± 3%, p = 0.029) and a significant difference in follicle stimulating hormone (FSH) with lower level in young subjects (4.09 ± 0.29) compared with old subjects (6.25 ± 0.4, p = 3.66E−05).

also in 26,082 other papers

We observed two highly significant module-trait correlations (|AverageCorr|> 0.6) with each linked to age and composed of hundreds of CpGs and involving > 100 gene loci (Additional file 4 : Table S6).

also in 132,142 other papers

We reasoned that the approach could identify important sets of CpGs, which may not reach marginal significance in site-wise analyses.

also in 5,068 other papers