Intracoronary injection showed a trend towards improved LVDP but did not reach statistical significance (LVDP: after EPC-TX 128.9 ± 14.7 mmHg versus LV-SDF-1-EPC 121.1 ± 24.5 mmHg versus control 111.8 ± 19.4 mmHg, P < 0.05, Fig. 5 B).
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Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing SDF-1 in a rat model.
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Although the LV-SDF-1-EPC transplanted hearts showed a trend towards better contractility there was no significant difference between EPC and EPC/SDF-1 groups regarding this parameter.