Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology.

In this work, schizophrenic patients taking this drug showed a trend toward greater gamma band activity, which did not reach statistical significance at the p = 0.05 level (their Figure 1 , p. 1589-90).

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Of the five virtual drugs with highly significant p values, four involved an AMPA τ 2 effect.

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