The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses: phase 2 dose-response studies.

In laboratories 1 and 3, the VP and the SVCG were marginally significant with either, but not both, the starting or terminal body weight adjustments at 40 mg/kg bw/day using the Dunnett’s multiple comparisons approach.

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In laboratories 2 and 7, the absolute GP weights decreased but did not achieve significance.

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The SVCG achieved marginal significance using the t -test approach but was not significant with the Dunnett’s approach.

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When the data were pooled across the participating laboratories, all five mandatory end points achieved statistical significance using the pairwise comparison approach from 10 mg VIN/kg bw/day when using 0.2 mg TP/kg bw/day, and although the GP response was marginally insignificant, the other four mandatory end points achieved significance from 30 mg VIN/kg bw/day when using 0.4 mg TP/kg bw/day.

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