Study of the gut microbiome profile in full-term infants with necrotizing enterocolits.

World J Clin Pediatr · 2026 · PMC13217207 · PMID 42220946

Europe PMC DOI

hedged sentences

0.1480

closest p · 3.0× alpha

0.1480

boldest claim

The sentences

approaching but not reaching significanceP = 0.148not close (p > 0.1)

The Firmicutes / Bacteroidetes ratio was markedly greater in NEC patients, especially NEC formula-fed patients, than in controls and NEC breastfed patients, with these differences approaching but not reaching significance ( P = 0.148) and demonstrating a moderate effect size (ε 2 = 0.14).

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did not reach statistical significanceno p-value reported

Although Bacteroidetes and Bacteroides did not reach statistical significance, their effect sizes suggest a need for further investigation into their roles in NEC pathogenesis in full-term infants.

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a clear trendno p-value reported

With respect to our results of the gut microbiome analysis, Bacteroidetes appeared more abundant in the control group (3.48E-01 vs 1.10E-01 in NEC), showing a clear trend that, while not statistically significant ( P = 0.118), was marked by a large effect size (RBC = +0.5), suggesting potential biological relevance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.