Genotype-phenotype correlations and protein domain-level predictors of cerebrovascular malformations in hereditary hemorrhagic telangiectasia.

J Neurol · 2026 · PMC13038781 · PMID 41915210

Europe PMC DOI

hedged sentences

0.0860

closest p · 1.7× alpha

0.1630

boldest claim

The sentences

did not reach statistical significancep = 0.086so close (0.05 < p ≤ 0.1)

In contrast, hepatic AVMs were more frequent among ACVRL1 carriers (44.6%), although this did not reach statistical significance ( p = 0.086).

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a statistical trendp = 0.086so close (0.05 < p ≤ 0.1)

Regarding hepatic AVMs, while ACVRL1 carriers exhibited a higher prevalence (44.6%) compared to ENG carriers (26.4%), this difference represented a statistical trend ( p = 0.086) rather than a significant correlation in our cohort.

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showed a trendp = 0.163not close (p > 0.1)

While the ACVRL1 genotype showed a trend toward protection (OR: 0.160), this did not reach statistical significance in the multivariable context ( p = 0.163), nor did the ENG genotype ( p = 0.503).

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