Natural History of Clinical Phenotypes and Their Biochemical Correlates in Adult X-Linked Adrenoleukodystrophy.

J Inherit Metab Dis · 2026 · PMC13000868 · PMID 41853938

Europe PMC DOI

hedged sentences

0.0710

closest p · 1.4× alpha

0.0790

boldest claim

The sentences

a trend towards significancep = 0.071so close (0.05 < p ≤ 0.1)

When controlled for AI, a trend towards significance did not reach the conventional threshold (no AI/HSCT vs. no AI/no HSCT: p = 0.071; AI/HSCT vs.

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did not reach statistical significancep = 0.079so close (0.05 < p ≤ 0.1)

In non‐AI patients, VLCFA levels were significantly elevated in arrested and acute cALD compared to AMN ( p = 0.013, Figures 3B and S3C ) but post hoc groupwise comparisons did not reach statistical significance (AMN vs. arrested cALD: p = 0.079, AMN vs. acute cALD: p = 0.052, arrested cALD vs. acute cALD: p = 1.0).

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