Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression.

2I ), with an observed trend toward increased LK fraction and LSK cells that did not reach statistical significance (Supplementary Fig. 2H ).

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In the second replating, monomethyl succinate showed a trend towards stimulation but cis-epoxy succinate reduced the colony-forming potential of HSC, with no effect on long-term colony forming potential measured after the third plating of the cells (Fig. 5E ).

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