NOTUM Enhances Cartilage Repair via Wnt/β-Catenin Modulation in a Rabbit Osteochondral Defect Model.

Int J Mol Sci · 2026 · PMC12840785 · PMID 41596299

Europe PMC DOI

hedged sentences

0.0556

closest p · 1.1× alpha

0.0556

boldest claim

The sentences

showed a trendp = 0.0556so close (0.05 < p ≤ 0.1)

For Surface/Morphology, the NOTUM group showed a trend toward higher scores compared with SHAM group ( p = 0.0556, 95% CI [−5.47, 0.07]) and significantly better results than the HA group ( p = 0.0496, 95% CI [−5.50, −0.01]).

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did not reach statistical significanceno p-value reported

Although the group treated with hAd-MSCs did not reach statistical significance in contrast with previous studies, its data exhibit a trend toward improvement is evident, which might be further enhanced by administering higher treatment doses.

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