Protective impact of circulating ω-3 PUFAs on sepsis susceptibility through <i>PCSK9</i> variant: evidence from Mendelian randomization and animal experiments.

Front Med (Lausanne) · 2025 · PMC12834780 · PMID 41608459

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marginal significanceno p-value reported

Although our results suggest that ω-6 PUFAs may reduce the occurrence of sepsis (OR, 0.914; 95% CI: 0.840–0.994; p = 0.036), it is important to acknowledge that the marginal significance of this finding may lead to overinterpretation.

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did not reach statistical significanceno p-value reported

Although the results did not reach statistical significance, this trend was evident ( Figure 5C ).

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