Network-level organization of systemic inflammation reflects early Alzheimer's-like behavioral changes.

Adding the five serum components in Model 2 increased total explained variance to 46.5% (R2=0.465, adjusted R2=0.278) and the overall model approached significance (F (7,20) = 2.49, p = 0.052), but the change in R2 was not significant (ΔR2=0.150, F‐change (5,20) = 1.13, p = 0.379).

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The cytokine‐linked hematopoietic signaling in cancer pathways profile showed a trend toward lower scores in TgAD rats relative to WT (F (1,24) = 4.136, p = 0.053, η p 2=0.147), with no sex effect or interaction (Fs (1,24) ≤ 0.129, ps ≥ 0.723; Fig. 1 D).

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HGF–RANTES showed a positive association in TgAD ( r = 0.690, p = 0.006), with an observed Z-change = 1.376 and a trend toward significance ( p = 0.084) relative to WT.

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Enrichment analysis using Enrichr identified highly significant overrepresentation of “Cytokine Activity,” “Cytokine–cytokine receptor interaction,” “Signaling by Interleukins,” and “Cytokine-mediated signaling pathway,” with all values well above the significance threshold (Fig. 1 B).

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