Predictors of Treatment Response to Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Pilot Study.

Faith’s phylogenetic diversity showed a negative trend with IBS-SSS reduction, but this correlation was not statistically significant (β = 6.525; 95% CI, –4.43 to 17.48; P = 0.234; Fig. 4D ).

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The HADS-depression score also showed a decreasing trend, from 9.4 to 8.3 at week 4, and to 7.4 at week 12, but failed to show a statistical significance ( P = 0.051, Fig. 2C ).

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When comparing the baseline fecal microbiome composition between responders and non-responders, both groups showed a trend of lower phylogenetic diversity compared to the donor; however, this difference was statistically significant only in the responder group ( P = 0.325 between donor and non-responder, P = 0.004 between donor and responder; Fig. 4A ).

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