AR did not differ between groups, and ex vivo HR showed a trend to the reduction in AAC‐PD6 but not in AAC‐PD2 animals (Figure 7D,E ).
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Electrical Remodeling of Pressure Overloaded Rat Heart Is Attenuated if Imposed During Proliferative Cardiac Growth.
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Despite an obvious trend in CV slowing at AAC‐PD6 compared to Sham, the changes did not reach statistical significance.
The level of myocardial fibrosis determined by Picrosirius Red (PSR) staining was rather decreased in both AAC groups but did not reach statistical significance (1.18 ± 0.2 PSR positivity/cardiomyocytes for Sham, 0.65 ± 0.2 for AAC‐PD2, and 0.67 ± 0.6 for AAC‐PD6, Figure S4 ).