Hepatic arterial interventional therapies alone or in combination with molecular targeted therapies and PD-(L)1 inhibitors in locally aggressive, early recurrent hepatocellular carcinoma: a retrospective study.

Front Immunol · 2025 · PMC12463941 · PMID 41019079

Europe PMC DOI

hedged sentences

0.0650

closest p · 1.3× alpha

0.0650

boldest claim

The sentences

did not reach statistical significanceP = 0.065so close (0.05 < p ≤ 0.1)

showed a trendP = 0.065so close (0.05 < p ≤ 0.1)

Although the HAIT-M-P group showed a trend toward better OS than the HAIT group, the difference did not reach statistical significance (HR = 0.45, 95% CI: 0.19 – 1.07, P = 0.065; Figure 2D ).

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a possible trendno p-value reported

Conclusion Compared with HAIT alone, HAIT-M-P was associated with improved PFS and tumor response rates, and showed a possible trend toward improved OS in patients with locally aggressive erHCC, which warrants further validation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.