Also, DNMT3A overexpression showed a highly significant association with a lower frequency of normal karyotype 23 .
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A significant correlation exists between CREBBP and CEBPA gene expression in de Novo adult acute myeloid leukemia.
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However, the negative correlation between CEBPA and DNMT3A showed a trend despite not being statistically significant.
We detected a negative trend in the correlation between CEBPA and DNMT3A despite being statistically insignificant (r S =0.261, p- value = 0.059), Fig. 2 D.