Changes in haptoglobin genotype-based gene expressions upon the observance of dawn-to-dusk intermittent fasting: a prospective cohort study on overweight and obese individuals.

Alongside, the mean of difference for the expression of the TFAM gene showed a clear trend of increment associated with the values of the expression through Hp1-1, Hp2-1, and Hp2-2, respectively, but without significant changes ( Figure 7 ).

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For Nrf2 , the mean differences in SOD2 and TFAM between Hp genotype groups showed an important trend of increment in Hp1-1, Hp2-1, and Hp2-2, in that order.

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Further, the means of differences for SOD2 gene expressions for the three polymorphism genotypes Hp showed a trend of increase in Hp1-1, Hp2-1, and Hp2-2 but without significant changes.

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The results of the expressions showed a highly significant increase in the CD163 , Nrf2 , SOD2 , and TFAM genes in the study participants at the end of Ramadan compared with the pre-fasting levels.

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