Conducting the analysis according to HI-R classification, the same trend toward HbF induction was observed, although it did not reach statistical significance ( p = 0.065) (Fig. 2 B).
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Fetal hemoglobin induction in azacytidine responders enlightens methylation patterns related to blast clearance in higher-risk MDS and CMML.
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The sentences
an increasing trendp = 0.101
Analyzing HbF kinetics during AZA treatment, among recruited patients, we observed an increasing trend to median values of 0.7%, 0.8% and 1.1% after 2, 4 and 6 cycles of treatment, respectively, compared to median pretreatment HbF levels of 0.6% ( p = 0.101) (Additional file 3, Figure S1).
a decreasing trendp = 0.380
When separate analysis was performed, non-responders (NR) displayed a decreasing trend of HbF levels during treatment ( p = 0.380), especially in HbF1 ( p = 0.114), although not statistically significant.
Responders (mCR) showed a trend of hypomethylation in CG1, CG2 and CG5 sites of the γ-globin gene promoter (Fig. 1 ), with mean methylation level reduction to 77% post-AZA treatment ( p mCR = 0.159) (Additional file 3, Figure S2).