Clinical significance of urinary inflammatory biomarkers in patients with IgA nephropathy.

uPCR demonstrated an insignificant trend with RANTES levels (ρ = -0.05, P = 0.51), whereas uPCR demonstrated a negative trend toward significance with EGF levels (ρ = -0.22, P = 0.001) (Fig. 3 B).

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These findings tended to be consistent with our study results, although they did not reach statistical significance.

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Urinary EGF levels may serve as a noninvasive biomarker for the extent of interstitial fibrosis, and this result was also consistent with a decreasing trend in urinary levels of EGF in patients with a higher score (1 or 2) of T-lesion in the Oxford classification for patients with IgAN [ 15 , 24 ].

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