Mitral Valve Surgery for Mitral Regurgitation Results in Reduced Left Ventricular Ejection Fraction in Barlow's Disease as Compared with Fibro-Elastic Deficiency.

In contrast, the BD patients in our study showed a trend towards less favorable reverse remodeling with higher LVESVi and lower LVEF at follow-up.

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Of note, subgroup analysis of only patients that underwent mitral valve repair ( n = 76) showed a clear trend but not a statistically significant difference between LVEF decrease in BD versus FED (−5.7 ± 8.5% vs. −3.7 ± 7.1%, p = 0.059) ( Supplementary Table S1 ).

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