Low glucose availability potentiates the effects of metformin on model T cell activation and exhaustion markers <i>in vitro</i>.

Front Endocrinol (Lausanne) · 2023 · PMC10728603 · PMID 38116319

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showed a trendno p-value reported

Low glucose even showed a trend towards lower mitochondrial mass.

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a weak trendno p-value reported

Metformin treatment had no significant effect on IL-2 secretion after 24h, although a weak trend may be noted towards higher IL-2 levels at both 0.3 mM and 5 mM ( Figure 10C ; Supplementary Figure 7G ).

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a clear trendno p-value reported

We found a clear trend towards lower baseline OCR and ATP production from oxidative phosphorylation ( Figures 8A, D ) with metformin treatment.

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